Chromosome 8

Matthew J Hilton, Washington University School of Medicine, St. Louis, Missouri, USA
Dan E Wells, University of Houston, Houston, Texas, USA

Published online: April 2007

DOI: 10.1002/9780470015902.a0005817.pub2

Chromosome 8 is a submetacentric chromosome containing about 5% of the euchromatic human genome that is associated with approximately 96 diseases or syndromes. Notably, it contains a region of strikingly high mutation rate in which the majority of the genes are involved in development or signalling of the nervous system.

Keywords: chromosome 8; syndrome; disease genes; sequencing

 References
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 Web links
    ePath National Center for Biotechnology Information (NCBI) Map Viewer http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=8.
    ePath Cancer Genome Anatomy Project Mitelman Map http://cgap.nci.nih.gov/Chromosomes/Mitelman.
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    ePath Marshfield Clinic, Center for Medical Genetics http://research.marshfieldclinic.org/genetics/.
    ePath Entrez Gene http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=gene.

Related Sub-Topics:

Genes, Molecules and Cellular Processes | Evolution and Development | Human Evolution | Population Structure and Genetics | Specific Genetic Disorders | Gene and Genome Structure and Organisation | Chromosomal Disorders | Gene Mapping by Disease Association | Inter-Individual Variation and Polymorphism
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Article Title: Chromosome 8
 
How to Cite close
Hilton, Matthew J, and Wells, Dan E(Apr 2007) Chromosome 8. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005817.pub2]