Chromosome 14

Human chromosome 14 is an acrocentric chromosome, rich in satellites on the short arm, which contains some 3.4% of the genetic material in the genome. It is characterized by several gene clusters including rRNA, T-cell receptor, and immunoglobulin heavy chain genes, plus several regions containing imprinted genes.

Keywords: immunoglobulin; T-cell receptor; protease inhibitor; imprinting, lymphoma

 References
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 Further Reading
    Arden B, Clark SP, Kabelitz D and Mak TW (1995) Human T-cell receptor variable gene segment families. Immunogenetics 42: 455–500.
    Bruls T, Gyapay G, Petit JL, et al. (2001) A physical map of human chromosome 14. Nature 409: 947–948.
    book Cox DW (2000) "1-antitrypsin deficiency". In: Scriver CR, Beaudet AL, Sly WS and Valle D (eds.) The Metabolic and Molecular Bases of Inherited Disease, 8th edn, vol. III, pp. 5559–5586. New York, NY: McGraw-Hill.
    Craddock N and Lendon C (1999) Chromosome Workshop: Chromosomes 11, 14, and 15. American Journal of Medical Genetics 88: 244–254.
    Heilig R, Eckenberg R, Petit JL, et al. (2003) The DNA sequence and analysis of human chromosome 14. Nature 421: 601–607.
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    Matsuda F and Honjo T (1996) Organization of the human immunoglobulin heavy-chain locus. Advances in Immunology 62: 1–29.
    Oakey RJ and Beechey CV (2002) Imprinted genes: identification by chromosome rearrangements and post-genomic strategies. Trends in Genetics 18: 359–366.
 Web Links
    ePath Celera. Human Genomic sequence database http://www.celera.com
    ePath Ensembl Genome Browser. Annotated human genomic sequence database http://www.ensembl.org/
    ePath Genome Database. Comprehensive human database of genome features http://www.gdb.org/
    ePath Marshfield Center for Medical Genetics. Human comprehensive genetic map database http://research.marshfieldclinic.org/genetics/Map_Markers/maps/IndexMapFrames.html
    ePath Mitelman Database of Chromosome Aberrations in Cancer. Comprehensive list of chromosome aberrations associated with cancer http://cgap.nci.nih.gov/Chromosomes/Mitelman
    ePath NCBI homepage. Comprehensive sequence database with annotation http://www.ncbi.nlm.nih.gov/
    ePath Online Mendelian Inheritance in Man (OMIM). Comprehensive database of diseases and genes http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
    ePath UCSC Genome Bioinformatics. Annotated human genomic sequence database http://genome.ucsc.edu
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Kamnasaran, Deepak, and Cox, Diane W(Jan 2006) Chromosome 14. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005823]