Chromosome 16

Abstract

Human chromosome 16 is a metacentric chromosome that contains 3.1% of the genetic material in the genome. It contains a large pericentromeric region of heterochromatin.

Keywords: chromosome 16; sequencing; disease; repeats; fragile sites

References

Callen DF, Lane SA, Kozman H, et al. (1995) Integration of transcript and genetic maps of chromosome 16 at near‐1‐Mb resolution: demonstration of a ‘hot‐spot’ for recombination at 16p12. Genomics 29: 503–511.

Cleton‐Jansen AM, Callen DF, Seshadri R, et al. (2001) Loss of heterozygosity mapping at chromosome arm 16q in 712 breast tumors reveals factors that influence delineation of candidate regions. Cancer Research 61: 1171–1177.

Doggett NA, Goodwin LA, Tesmer JG, et al. (1995) An integrated physical map of human chromosome 16. Nature 377: 335–365.

Horvath JE, Schwartz S and Eichler EE (2000) The mosaic structure of human pericentromeric DNA: a strategy for characterizing complex regions of the human genome. Genome Research 10: 839–852.

Kozman HM, Phillips HA, Callen DF, Sutherland GR and Mulley JC (1993) Integration of the cytogenetic and genetic linkage maps of human chromosome 16 using 50 physical intervals and 50 polymorphic loci. Cytogenetics and Cell Genetics 62: 194–198.

Loftus BJ, Kim UJ, Sneddon VP, et al. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics 60: 295–308.

Shen Y, Kozman HM, Thompson A, et al. (1994) A PCR‐based genetic linkage map of human chromosome 16. Genomics 22: 68–76.

Stallings RL, Doggett NA, Callen D, et al. (1992) Evaluation of a cosmid contig physical map of human chromosome 16. Genomics 13: 1031–1039.

Stallings RL, Whitmore SA, Doggett NA and Callen DF (1993) Refined physical mapping of chromosome 16‐specific low‐abundance repetitive DNA sequences. Cytogenetics and Cell Genetics 63: 97–101.

Sutherland GR and Richards RI (1999) Fragile sites–cytogenetic similarity with molecular diversity. American Journal of Human Genetics 64: 354–359.

Wilkie AO, Higgs DR, Rack KA, et al. (1991) Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16. Cell 64: 595–606.

Further Reading

Barber JC, Reed CJ, Dahoun SP and Joyce CA (1999) Amplification of a pseudogene cassette underlies euchromatic variation of 16p at the cytogenetic level. Human Genetics 104: 211–218.

Web Links

Cancer Genome Anatomy Project. Chromosome breakpoints associated with malignancy http://cgap.nci.nih.gov/Chromosomes/RecurrentAberrations

HUGO Chromosome 16 resources http://www.gdb.org/hugo/chr16/

NCBI Genome Guide. Chromosome 16 sequencing and gene information http://www.ncbi.nlm.nih.gov/genome/guide/HsChr16.shtml

Online Mendelian Inheritance in Man (OMIM) Database http://www.ncbi.nlm.nih.gov/Omim/

Online Mendelian Inheritance in Man (OMIM). Disease genes on chromosome 16 http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/getmap?chromosome=16

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How to Cite close
Callen, David F(Jan 2006) Chromosome 16. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005825]