Claes Wadelius, Rudbeck Laboratory, Uppsala, Sweden
Published online: January 2006
DOI: 10.1038/npg.els.0005826
Human chromosome 17 is a submetacentric chromosome containing 2.6% of the genetic material in the genome. It has a greater number of genes than expected for its size, a G+C content above average and a large number of CpG islands. It is characterized by several gene clusters including those encoding homeobox B, olfactory receptors, type I keratins and SnRNAs.
Keywords: p53; retinoic acid receptor alpha; CpG islands; duplication; deletion
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| Further Reading | |
| Pandolfi PP (2001) Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Human Molecular Genetics 10: 769–775. | |
| Web Links | |
| ePath IARC TP53 Mutation Database. The IARC TP53 database includes all TP53 gene mutations identified in human cancers and published in the peer-reviewed literature http://www.iarc.fr/p53/Index.html | |
| ePath NCBI LocusLink. A single query interface to curated sequences and descriptive information about genetic loci. Contains information on official nomenclature, aliases, sequence accessions, phenotypes, MIM numbers, homology, map locations, related web sites, etc. http://www.ncbi.nlm.nih.gov/LocusLink/ | |
| ePath Online Mendelian Inheritance in Man (OMIM). A database with information on human genes and genetic disorders, including text and links to other databases http://www.ncbi.nlm.nih.gov/OMIM/ | |
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