Chromosome 17

Abstract

Human chromosome 17 is a submetacentric chromosome containing 2.6% of the genetic material in the genome. It has a greater number of genes than expected for its size, a G+C content above average and a large number of CpG islands. It is characterized by several gene clusters including those encoding homeobox B, olfactory receptors, type I keratins and SnRNAs.

Keywords: p53; retinoic acid receptor alpha; CpG islands; duplication; deletion

References

Cambien F, Poirier O, Lecerf L, et al. (1992) Deletion polymorphism in the gene for angiotensin‐converting enzyme is a potent risk factor for myocardial infarction. Nature 359: 641–644.

Chance PF, Alderson MK, Leppig KA, et al. (1993) DNA deletion associated with hereditary neuropathy with liability to pressure palsies. Cell 72: 143–151.

International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921.

Julier C, Delepine M, Keavney B, et al. (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Human Molecular Genetics 6: 2077–2085.

Lupski JR, de Oca‐Luna RM, Slaugenhaupt S, et al. (1991) DNA duplication associated with Charcot–Marie–Tooth disease type 1A. Cell 66: 219–232.

Pavlicek A, Paces J, Clay O and Bernardi G (2002) A compact view of isochores in the draft human genome sequence. FEBS Letters 511: 165–169.

Further Reading

Pandolfi PP (2001) Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Human Molecular Genetics 10: 769–775.

Web Links

IARC TP53 Mutation Database. The IARC TP53 database includes all TP53 gene mutations identified in human cancers and published in the peer‐reviewed literature http://www.iarc.fr/p53/Index.html

NCBI LocusLink. A single query interface to curated sequences and descriptive information about genetic loci. Contains information on official nomenclature, aliases, sequence accessions, phenotypes, MIM numbers, homology, map locations, related web sites, etc. http://www.ncbi.nlm.nih.gov/LocusLink/

Online Mendelian Inheritance in Man (OMIM). A database with information on human genes and genetic disorders, including text and links to other databases http://www.ncbi.nlm.nih.gov/OMIM/

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Wadelius, Claes(Jan 2006) Chromosome 17. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005826]