Chromosome 19

Abstract

Human chromosome 19 is a metacentric chromosome that contains 1.9% of the genetic material in the genome. It has the highest G+C content of all the chromosomes and also the highest content, relative to size, of repetitive sequences, CpG islands and genes. It is characterized by gene clusters including cytochrome P‐450, olfactory receptors and Kruppel‐like zinc finger proteins.

Keywords: chromosome 19; genome mapping; genetic map; physical map; sequence‐ready map; genes; gene families; genetic diseases; genome sequencing; mouse homology

References

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Further Reading

Further information about chromosome 19 can be found by following the Web Links below.

Web Links

Cancer Genome Anatomy Project. Mitelman database of chromosome aberrations in cancer. Information on chromosome aberrations in cancer and their relation to tumor characteristics. http://cgap.nci.nih.gov/Chromosomes/Mitelman

CEPH Genotype Database. Genotypes for all genetic markers that have been typed in the CEPH reference families for linkage mapping of human chromosomes http://www.cephb.fr/cephdb/

Cooperative Human Linkage Center. Information on microsatellite genetic markers and mapsdeveloped by the Cooperative Human Linkage Center http://gai.nci.nih.gov/CHLC/

DOE Joint Genome Institute. Information on sequencing of human chromosome 19 and homologous regions of the mouse genome http://www.jgi.doe.gov/

Ensembl Genome Browser. Viewer display of automated annotation of human genome sequence http://www.ensembl.org/

GDB Human Genome Database. Updated daily. Descriptions of regions of the human genome, including genes, markers, clones and contigs, maps of the human genome and variations within the genome http://www.gdb.org/

Genew: Human Gene Nomenclature Database Search Engine. Approved names and symbols for human genes, together with aliases and previous symbols http://www.gene.ucl.ac.uk/cgi‐bin/nomenclature/searchgenes.pl

Human Genome Organization (HUGO) Chromosome 19 home page. Provides links to a variety of chromosome 19 resource sites http://www.gdb.org/hugo/chr19/

Jackson Laboratory Mouse Genome Informatics. Information on mouse genes, genetic markers, phenotypes, and comparative mapping data http://www.informatics.jax.org/

Lawrence Livermore National Laboratory. Maps of human chromosome 19. Access to restriction maps, FISH maps and metric physical map of chromosome 19 http://bbrp.llnl.gov/bbrp/genome/html/chrom_map.html

Marshfield Clinic. Center for Medical Genetics. Comprehensive human genetic linkage maps and comparison of genetic and physical maps for human chromosomes http://research.marshfieldclinic.org/genetics/

National Center for Biotechnology Information: Online Mendelian Inheritance in Man (OMIM). Catalog of human genes and genetic disorders http://www.ncbi.nlm.nih.gov/Omim/

NCBI Human Genome. Status of human genome sequencing and guide to online resources and tools for analysis of genome sequence http://www.ncbi.nlm.nih.gov/genome/seq/

NCBI LocusLink. Information about genetic loci, including official nomenclature, sequence accessions, phenotypes, homology, and map locations http://www.ncbi.nlm.nih.gov/LocusLink/

NCBI Single Nucleotide Polymorphism dbSNP. Database of single nucleotide polymorphisms identified in human DNA sequence http://www.ncbi.nlm.nih.gov/SNP/

SNP Consortium Ltd. Information on single nucleotide polymorphisms discovered and characterized by the SNP Consortium http://snp.cshl.org/

Stanford Human Genome Center. Finishing status of chromosome 19 genomic clones, with access to sequence currently in the finishing process http://www‐shgc.stanford.edu/index.html

Weizmann Institute of Science, Bioinformatics Unit and Genome Center. GeneCards. Database of human genes, gene products and their involvement in diseases http://bioinformatics.weizmann.ac.il/cards/

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How to Cite close
Olsen, Anne S(Jan 2006) Chromosome 19. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005828]