Lung Cancer: Genetics

Michele L Cote, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA
Ann G Schwartz, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA

Published online: April 2007

DOI: 10.1002/9780470015902.a0005834

There exists sufficient evidence supporting a genetic component to lung cancer development. However, the genes involved and the exact mechanisms underlying individual susceptibility to lung cancer development are still unclear. Advances in cellular biology and laboratory methods are rapidly evolving and will provide further insight about the genetic basis of this disease.

Keywords: lung cancer; genetics; genomics; DNA repair; glutathione-S transferases

 Further Reading
    Bailey-Wilson JE, Amos CI, Pinney SM et al. (2004) A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics 75: 460–474.
    Belinsky SA (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nature Reviews in Cancer 4: 707–717.
    Bowman RV, Yang IA, Semmler AB and Fong KM (2006) Epigenetics of lung cancer. Respirology 11: 355–365.
    Granville CA and Dennis PA (2005) An overview of lung cancer genomics and proteomics. American Journal of Respiratory Cell and Molecular Biology 32: 169–176.
    Haiman CA, Stram DO, Wilkens LR et al. (2006) Ethnic and racial differences in the smoking-related risk of lung cancer. New England Journal of Medicine 354: 333–342.
    Houlston RS (1999) Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis. Cancer Epidemiology Biomarkers Prevention 8: 675–682.
    Houlston RS (2000) CYP1A1 polymorphisms and lung cancer risk: a meta-analysis. Pharmacogenetics 10: 105–114.
    Hung RJ, Hall J, Brennan P and Boffetta P (2005) Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. American Journal of Epidemiology 162: 925–942.
    Matakidou A, Eisen T and Houlston RS (2005) Systematic review of the relationship between family history and lung cancer risk. British Journal of Cancer 93: 825–833.
    Thomas RK, Weir B and Meyerson M (2006) Genomic approaches to lung cancer. Clinical Cancer Research 12(14 Suppl): 4384s–4391s.

Related Sub-Topics:

Cell Biology of Cancer | Molecular Genetics of Common and Complex Disease | Cancer Genetics | Linkage Analysis | Gene Mapping by Disease Association | Gene Expression Profiling of Genetic Disease
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Article Title: Lung Cancer: Genetics
 
How to Cite close
Cote, Michele L, and Schwartz, Ann G(Apr 2007) Lung Cancer: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005834]