Shotgunning the Human Genome: A Personal View


Using the whole‐genome shotgun method as the primary approach to sequencing large genomes, notably the human genome, Celera has demonstrated the validity of this method, which is now used in genome‐sequencing laboratories worldwide for all classes of organisms.

Keywords: shotgun sequencing; Haemophilus influenzae; Drosophila melanogaster; assembly; Celera


Adams MD, Celnicker SE, Holt RA, et al. (2000) The genome sequence of Drosophila melanogaster. Science 287: 2185–2195.

International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409: 860–921.

Venter JC, Smith HO and Hood L (1996) A new strategy for genome sequencing. Nature 381: 364–366.

Venter JC, Adams MD, Myers EW, et al. (2001) The sequence of the human genome. Science 291: 1304–1351.

Web Links Here can be found the complete sequence of Celera's Human Reference Genome, as published in Science. Researchers can compare this early, highly accurate version of the Celera human genome assembly with that of the public genome project [AB1]

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Venter, J Craig(Jan 2006) Shotgunning the Human Genome: A Personal View. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005850]