Multiple Significance Testing in Genetic Epidemiology


The simultaneous testing of multiple hypotheses in one and the same study tends to inflate the overall probability of obtaining one or more false positive results. Several methods have been devised to control this study‐wise global false positive rate through the adjustment of the test‐specific significance threshold applied to p‐values. The necessity of adjusting the significance levels in genetic analyses of complex human traits has, however, been a matter of scientific debate.

Keywords: Bonferroni correction; linkage analysis; fine mapping; allelic association; LOD score


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Krawczak, Michael(Jan 2006) Multiple Significance Testing in Genetic Epidemiology. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005930]