Clustering of Highly Expressed Genes in the Human Genome

Hinco J Gierman, University of Amsterdam, Amsterdam, The Netherlands
Rogier Versteeg, University of Amsterdam, Amsterdam, The Netherlands

Published online: May 2008

DOI: 10.1002/9780470015902.a0005931.pub2

A dual mechanism of gene regulation exists in the human genome: Transcription factors determine whether a gene will be expressed and establish a basic level of transcription. In addition, the chromosomal domain in which a gene is positioned exerts a substantial effect and potentiates the ultimate expression level.

Keywords: chromosomal domains; gene expression; transcription; genome organization; gene clustering

Figure 1. Physically mapped transcriptome profile of the q-arm of human chromosome 1. Giemsa banding is illustrated below each transcriptome map (centromere/heterochromatic region is marked ‘cen’). RIDGEs are marked with an ‘R’, anti-RIDGEs are marked ‘AR’. Black vertical bars represent genes and their height indicates domain activity for a window of 49 genes (median expression of the surrounding 49 genes in 133 pooled SAGE libraries from different tissues). Below is the chromosomal position in megabases (UCSC Genome Build HG15). Illustration by Jan Koster and Hinco Gierman.
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 Web Links
    ePath The Human Transcriptome Map. A Web application that gives the gene expression profiles for any chromosomal region: http://bioinfo.amc.uva.nl/HTMseq/

Related Sub-Topics:

Nucleic Acid Structure | Gene and Genome Structure and Organisation | Transcriptional Regulation | Chromosomes and Chromatin Modifications | DNA Structure and Function
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Article Title: Clustering of Highly Expressed Genes in the Human Genome
 
How to Cite close
Gierman, Hinco J, and Versteeg, Rogier(May 2008) Clustering of Highly Expressed Genes in the Human Genome. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005931.pub2]