Microarrays and Expression Profiling in Cancer

Abstract

DNA microarrays can be used to measure messenger ribonucleic acid levels of many thousands of genes in a single experiment. This information can be used in cancer biology and for the classification of tumors.

Keywords: cancer; DNA microarray; classification; expression; therapeutic targets; cancer biology

References

Gruvberger S, Ringner M, Chen Y, et al. (2001) Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Research 61: 5979–5984.

Hedenfalk I, Duggan D, Chen Y, et al. (2001) Gene‐expression profiles in hereditary breast cancer. New England Journal of Medicine 344: 539–548.

Kannan K, Kaminski N, Rechavi G, et al. (2001) DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf‐1. Oncogene 20: 3449–3455.

Mullan PB, McWilliams S, Quinn J, et al. (2001) Uncovering BRCA1‐regulated signalling pathways by microarray‐based expression profiling. Biochemical Society Transactions 29: 678–683.

Perou CM, Sorlie T, Eisen MB, et al. (2000) Molecular portraits of human breast tumours. Nature 406: 747–752.

Further Reading

Clarke PA, te Poele R, Wooster R and Workman P (2001) Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential. Biochemical Pharmacology 62: 1311–1336.

Web Links

Nature Genetics: The Chipping Forecast: a review of the manufacture and use of DNA microarrays http://www.nature.com/cgi‐taf/DynaPage.taf?file=/ng/journal/v21/n1s/index.html

The Brown Lab Web page: protocols and further web links for DNA microarrays http://cmgm.stanford.edu/pbrown/

National Cancer Institute. Genomics and Bioinformatics Group: how DNA microarrays are being used in cancer drug discovery projects http://discover.nci.nih.gov/

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How to Cite close
Giddings, Ian, and Wooster, Richard(Jan 2006) Microarrays and Expression Profiling in Cancer. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005947]