Microarrays in Toxicological Research

Abstract

Toxicologists are increasingly applying oligonucleotide and complementary DNA microarrays in an attempt to understand adverse chemical reactions that occur during gene transcription. When applied in concert with the more established approaches of biochemical toxicology, pathology and so on, the appropriate use of these microarrays is improving our fundamental knowledge of mechanisms of toxicity and will have profound impact on safety assessment processes in the discovery and development of new pharmaceuticals.

Keywords: toxicology; microarray; gene expression; bioinformatics; database transcription, drug development

References

Baker TK, Carfagna MA, Gao H, et al. (2001) Temporal gene expression analysis of monolayer cultured rat hepatocytes. Chemical Research and Toxicology 14: 1218–1231.

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Further Reading

Bassett Jr DE, Eisen MB and Boguski MS (1999) Gene expression informatics – it's all in your mine. Nature Genetics 21(supplement 1): 51–55.

Brown PO and Hartwell L (1998) Genomics and human disease – variations on variation. Nature Genetics 18(2): 91–93.

Fielden MR and Zacharewski TR (2001) Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicological Science 60(1): 6–10.

Gershon D (2002) Toxicogenomics gains impetus. Nature 415(6869): 4–5.

Hamadeh HK, Amin RP, Paules RS and Afshari CA (2002) An overview of toxicogenomics. Current Issues in Molecular Biology 4(2): 45–56.

Smith LL (2001) Key challenges for toxicologists in the 21st century. Trends in Pharmacological Sciences 22(6): 281–285.

Tennant RW (2002) The National Center for Toxicogenomics: using new technologies to inform mechanistic toxicology. Environmental Health Perspectives 110(1): A8–A10.

Web Links

ILSI. Home page of International Life Sciences Institute http://www.ilsi.org

Stanford Microarray Database. Example of a publicly accessible database of microarray experimental data. Homepage of European Bioinformatics Institute microarray group http://www.ebi.ac.uk/microarray/index.html

http://genome‐www4.stanford.edu/MicroArray/SMD

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How to Cite close
Pennie, William D(Jan 2006) Microarrays in Toxicological Research. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005950]