Microarrays in Drug Discovery and Development

Abstract

Microarrays are used to analyze the expression of thousands of genes in parallel, allowing studies of tissue distribution patterns associated with normal physiology and diseases and with the effects of compounds, in terms of safety and efficacy in model organisms and in humans.

Keywords: expression profiling; gene chips; target validation; toxicogenomics; pharmacogenomics

References

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Further Reading

Liotta L and Petricoin E (2000) Molecular profiling of human cancer. Nature Reviews Genetics 1: 48–56.

Nicholson JK, Connelly J, Lindon JC and Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nature Reviews Drug Discovery 1: 153–161.

Orr MS and Scherf U (2002) Large‐scale gene expression analysis in molecular target discovery. Leukemia 16: 473–477.

Petricoin EF, Ardekani AM, Hitt BA, et al. (2002) Use of proteomic patterns in serum to identify ovarian cancer. Lancet 359: 572–577.

Sambrook J and Russell DW (eds.) (2001) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. [Relevant chapters include Chapter 7 (Extraction, purification, and analyses of mRNA from eucaryotic cells) and Appendix 10 (DNA array technology).]

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Ulrich R and Friend SH (2002) Toxicogenomics and drug discovery: will new technologies help us produce better drugs? Nature Reviews Drug Discovery 1: 84–88.

Ye RW, Wang T, Bedzyk L and Croker KM (2001) Applications of DNA microarrays in microbial systems. Journal of Microbiological Methods 47: 257–272.

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How to Cite close
Debouck, Christine, and Roses, Allen D(Jan 2006) Microarrays in Drug Discovery and Development. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005951]