Germ Plasm and the Molecular Determinants of Germ Cell Fate

Abstract

Germ plasm is a cluster of fibrogranular bodies present in the cytoplasm of oocytes and incorporated into a few cells during early embryogenesis. These cells become the precursors to primordial germ cells, the founders of the germ cell lineage. Germ cell‐fate determinants associated with the germ plasm specify that the cells in which they reside shall become primordial germ cells.

Keywords: germ plasm; cell‐fate determinants; germ cell line; primordial germ cell

References

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Further Reading

Anderson R, Heasman J and Wylie C (2001) Early events in mammalian germ line. International Review of Cytology 203: 215–230.

Deng W and Lin H (2002) miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Developmental Cell 2: 819–830.

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Web Links

Jaruzelska J, Kotecki M, Kusz K, Spik A and Reijo Pera RA (2002) Conservation of the Pumilio‐Nanos complex in germ cells from flies to humans. Human Reproduction Abstracts 2002 http://conf.eshre.com/PDF/O‐017.pdf

Bol, boule‐like (Drosophila) (BOLL); Locus ID: 66037. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=66037

Deleted in azoospermia (DAZ); Locus ID: 1617. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1617

Deleted in azoospermia‐like (DAZL); Locus ID: 1618. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1618

Bol, boule‐like (Drosophila) (BOLL); MIM number: 606165. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?606165

Deleted in azoospermia (DAZ); MIM number: 400003. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?400003

Deleted in azoospermia‐like (DAZL); MIM number: 601486. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?601486

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How to Cite close
Eddy, Edward Mitchell(Jan 2006) Germ Plasm and the Molecular Determinants of Germ Cell Fate. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005960]