Familial Adenomatous Polyposis

Abstract

Familial adenomatous polyposis is an inherited cancer predisposition syndrome characterized by multiple benign tumors (adenomas) of the large bowel.

Keywords: colon; rectum; colorectal; adenoma; carcinoma; polyposis; adenomatosis polyposis coli

References

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Further Reading

Bodmer W (1999) Familial adenomatous polyposis (FAP) and its gene, APC. Cytogenetics and Cell Genetics 86: 99–104.

Dukes CE (1952) Familial intestinal polyposis. Annals of the Royal College of Surgeons of England 10: 293–304.

Fearnhead NS, Britton MP and Bodmer WF (2001) The ABC of APC. Human Molecular Genetics 10: 721–733.

Fodde R (2002) The APC gene in colorectal cancer. European Journal of Cancer 38: 867–871.

Fodde R, Smits R and Clevers H (2001) APC, signal transduction and genetic instability in colorectal cancer. National Review of Cancer 1: 55–67.

Goss KH and Groden J (2000) Biology of the adenomatous polyposis coli tumor suppressor. Journal of Clinical Oncology 18: 1967–1979.

Phillips RKS, Spigelman AD and Thomson JPS (eds.) (1994) Familial Adenomatous Polyposis and Other Polyposis Syndromes London: Edward Arnold.

Spirio L, Olschwang S, Groden J, et al. (1993) Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75: 951–957.

Wong NA and Pignatelli M (2002) Beta‐catenin: a linchpin in colorectal carcinogenesis? American Journal of Pathology 160: 389–401.

Web Links

APC (adenomatosis polyposis coli); Locus ID: 324. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=324

APC (adenomatosis polyposis coli); MIM number: 175100. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?175100

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How to Cite close
Frayling, Ian M(Jan 2006) Familial Adenomatous Polyposis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005966]