Promoter Haplotypes and Gene Expression

Paulus HLJ Joosten, University of Nijmegen, Nijmegen, The Netherlands

Published online: January 2006

DOI: 10.1038/npg.els.0005968

There is an estimated 0.1% difference between any two human genomes. The differences occur predominantly outside protein-coding regions and result in, for example, different promoter haplotypes. The generation of a high-resolution human genomic sequence will allow us to investigate the role of genetic variance in common diseases, which tend to be multifactorial with a non-Mendelian inheritance.

Keywords: polymorphism; genetics; disease; haplotype; transcription

 References
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 Web Links
    ePath National Center for Biotechnology Information. single nucleotide polymorphisms Database. NCBI supports the public redistribution of dbSNP by providing zip- compressed data dumps in four data formats http://www.ncbi.nlm.nih.gov/SNP/

Related Sub-Topics:

Molecular Genetics of Common and Complex Disease | Gene and Genome Structure and Organisation | Techniques and Tools in Clinical Genetics | Quantitative Genetics | Transcriptional Regulation | DNA Structure and Function | Techniques and Tools in Molecular Biology
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Article Title: Promoter Haplotypes and Gene Expression
 
How to Cite close
Joosten, Paulus HLJ(Jan 2006) Promoter Haplotypes and Gene Expression. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005968]