Variable Drug Response: Genetic Evaluation

Abstract

The field of pharmacogenomics attempts to evaluate the contribution of genetic variants to drug sensitivity and adverse effects. Over the past decade, the pharmacogenomics field has evolved from using candidate gene approaches to application of genome‚Äźwide approaches for the identification of genetic variants associated with drug responses. Understanding the underlying biology of these associations as well as their translation into clinical practice represents a major ongoing and future challenge.

Key Concepts:

  • A discussion on pharmacogenomics studies on drug response and adverse drug reactions.

  • History of pharmacogenomics

  • The ethnic component of pharmacogenomics

  • The impact of genetics on drug response

  • The impact of genetics on adverse drug reactions

  • Clinical implementation of pharmacogenomics

Keywords: pharmacogenomics; personalised medicine; pharmacoethnicity; drug response; adverse drug reactions

Figure 1.

The evolution of pharmacogenomics. The diagram depicts the different advantages and disadvantages for candidate gene approaches, candidate pathway genes approaches, genome‐wide association studies (GWAS) and next‐generation sequencing.

Reproduced with permission from Madian et al.2012. © Elsevier.
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Madian, Ashraf G, and Baker Jones, Richard(Oct 2013) Variable Drug Response: Genetic Evaluation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006001.pub2]