Histone Acetylation and Disease

Annick Harel‐Bellan, Institut Andre Lwoff, Villejuif, France
Valentina Guasconi, Institut Andre Lwoff, Villejuif, France
Lauriane Fritsch, Institut Andre Lwoff, Villejuif, France
Redha Sekhri, Institut Andre Lwoff, Villejuif, France
Heike Lehrmann, Institut Andre Lwoff, Villejuif, France
Slimane Ait‐Si‐Ali, Institut Andre Lwoff, Villejuif, France

Published online: January 2006

DOI: 10.1038/npg.els.0006032

Abstract

Acetylation of nucleosomal core histones plays a key regulatory role in many physiological processes such as proliferation and differentiation. Aberrant acetylation or deacetylation of histones leads to severe human diseases such as leukemia, epithelial cancers, fragile X‐syndrome and Rubinstein–Taybi syndrome.

Keywords: histone acetyltransferase; histone deacetylase; histone, chromatin; leukemia

Figure 1.

Mode of action of (HAT) enzymes. At the level of gene promoter sequences, HAT can acetylate histones in nucleosomes (depicted by white cylinders), as well as nonhistone proteins such as proteins of the RNA polymerase complex (RNA pol II), sequence‐specific (TF) or cofactors. Arrows represent enzymatic activity. Ac: acetyl group; RNA: ribonucleic acid polymerase II; TF: transcription factors.
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References

Ait‐Si‐Ali S, Polesskaya A, Filleur S, et al. (2000) CBP/p300 histone acetyl‐transferase activity is important for the G1/S transition. Oncogene 19(20): 2430–2437.

Jenuwein T and Allis CD (2001) Translating the histone code. Science 293(5532): 1074–1080.

Magnaghi‐Jaulin L, Ait‐Si‐Ali S and Harel‐Bellan A (2000) Histone acetylation and the control of the cell cycle. Progress in Cell Cycle Research 4: 41–47.

Marmorstein R and Roth SY (2001) Histone acetyltransferases: function, structure, and catalysis. Current Opinion in Genetics and Development 11(2): 155–61.

Narlikar GJ, Fan HY and Kingston RE (2002) Cooperation between complexes that regulate chromatin structure and transcription. Cell 108(4): 475–487.

Timmermann S, Lehrmann H, Polesskaya A, et al. (2001) Histone acetylation and disease. Cellular and Molecular Life Sciences: CMLS 58(5,6): 728–736.

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Web Links

CREBBP, (CREB binding protein (Rubinstein–Taybi syndrome)); Locus ID: 1387. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1387

FMR1 (fragile X mental retardation 1); Locus ID: 2332. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2332

MECP2 (methyl CpG binding protein 2 (Rett syndrome)); Locus ID: 4204. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4204

SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4); Locus ID: 6597. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6597

TP53 (tumor protein p53 (Li–Fraumeni syndrome)); Locus ID: 7157. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7157

CREBBP (CREB binding protein (Rubinstein–Taybi syndrome)); MIM number: 600140. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600140

FMR1 (fragile X mental retardation 1); MIM number: 309550. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?309550

MECP2 (methyl CpG binding protein 2 (Rett syndrome)); MIM number: 300005. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?300005

SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4); MIM number: 603254. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?603254

TP53 (tumor protein p53 (Li–Fraumeni syndrome)); MIM number: 191170. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?191170

Related Sub-Topics:

Cancer Genetics | Cell Biology of Cancer | Cell Cycle | Epigenetics and Disease | Chromosomes and Chromatin Modifications | Transcriptional Regulation | Molecular Genetics of Common and Complex Disease | Gene and Genome Structure and Organisation | Growth and Synthesis
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Article Title: Histone Acetylation and Disease
 
How to Cite close
Harel‐Bellan, Annick, Guasconi, Valentina, Fritsch, Lauriane, Sekhri, Redha, Lehrmann, Heike, and Ait‐Si‐Ali, Slimane(Jan 2006) Histone Acetylation and Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0006032]