Atherosclerosis: Gene Therapy

Abstract

Knowledge of the human genome has opened up the possibility of developing gene therapy for several inherited and acquired diseases, such as atherosclerosis and its complications.

Keywords: gene therapy; atherosclerosis; inherited diseases; dyslipidemias; coronary heart disease

References

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Grossman M, Rader DJ, Muller D, et al. (1995) A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolemia. Gene Therapy 2: 587.

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Laitinen M, Mäkinen K, Manninen H, et al. (1998) Adenovirus‐mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Human Gene Therapy 9: 1481–1486.

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Further Reading

Friedmann T (1994) Gene Therapy. Fact and Fiction in Biology's New Approaches to Disease. New York, NY: Cold Spring Harbor Laboratory Press.

Gibbons GH and Dzau VJ (1996) Molecular therapies for vascular diseases. Science 272: 689–693.

Rekhter MD, Simari RD, Work CW, et al. (1998) Gene transfer into normal and atherosclerotic human blood vessels. Circulation Research 82: 1243–1252.

Rutanen J, Puhakka H and Ylä‐Herttuala S (2002) Post‐intervention vessel remodeling. Gene Therapy 9: 1487–1491.

Web Links

Apolipoprotein A‐I (APOA1); Locus ID: 335. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=335

Lecithin‐cholesterol acyltransferase (LCAT); Locus ID: 3931. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3931

Lipoprotein lipase (LPL); Locus ID: 4023. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4023

Low density lipoprotein receptor (familial hypercholesterolemia) (LDLR); Locus ID: 3949. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3949

Vascular endothelial growth factor (VEGF); Locus ID: 7422. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7422

Very low density lipoprotein receptor (VLDLR); Locus ID: 7436. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7436

Apolipoprotein A‐I (APOA1); MIM number: 107680. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?107680

Lecithin‐cholesterol acyltransferase (LCAT); MIM number: 606967. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?606967

Lipoprotein lipase (LPL); MIM number: 238600. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?238600

Low density lipoprotein receptor (familial hypercholesterolemia) (LDLR); MIM number: 606945. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?606945

Vascular endothelial growth factor (VEGF); MIM number: 192240. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?192240

Very low density lipoprotein receptor (VLDLR); MIM number: 192977. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?192977

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How to Cite close
Ylä‐Herttuala, Seppo(Sep 2006) Atherosclerosis: Gene Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006042]