Apoptosis and the Cell Cycle in Human Disease

Abstract

The cell cycle and apoptosis are central gene‐regulated cellular pathways. A number of diseases evolve due to deregulation of these pathways.

Keywords: apoptosis; cell cycle; cancer; autoimmune disease; neurodegenerative disease

Figure 1.

Critical regulators and checkpoints of cell cycle progression. Cell cycle consists of G1, S, G2 and M phases as indicated with checkpoints in G1, G2 and M shown as horizontal T‐bars. Sequential activation of the indicated CDK‐Cyclin complexes drives the cell cycle (black arrows). Cell cycle progression can be blocked by negative regulators such as p16, pRb and p27/KIP1 or by exit from the cell cycle into G0 phase. Growth‐stimulatory signals can lead to re‐entry into the cell cycle. CDK: cyclin‐dependent kinase; pRb: retinoblastoma protein; KIP1: kinase inhibitor protein 1.

Figure 2.

Cellular pathways of apoptosis. FasL: Fas‐ligand; IAP: inhibitor of apoptosis; TNF: tumor necrosis factor; TRAIL: tumor necrosis factor‐related apoptosis‐inducing ligand. Inverted T is used to indicate inhibitory process while the arrow indicates activating process.

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Further Reading

Bullock AN and Fersht AR (2001) Rescuing the function of mutant p53. Nature Reviews Genetics 1: 68–76.

Hengartner MO (2000) The biochemistry of apoptosis. Nature 407: 770–776.

Korsmeyer SJ and Zinkel SS (2001) Molecular biology of cancer: apoptosis. In: De Vita V, Hellman S and Rosenberg SA (eds.) Principles and Practice of Oncology, 6th edn, pp. 111–122. Philadelphia, PA: Lippincott, Williams & Wilkins Publishers.

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Web Links

BAX (BCL2‐associated X protein); Locus ID: 581. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=581

BCL2 (B‐cell CLL/lymphoma 2); Locus ID: 596. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=596

TP53 (tumor protein p53 (Li‐Fraumeni syndrome)); Locus ID: 7157. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7157

BAX (BCL2‐associated X protein); MIM number: 600040. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600040

BCL2 (B‐cell CLL/lymphoma 2); MIM number: 151430. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?151430

TP53 (tumor protein p53 (Li–Fraumeni syndrome)); MIM number: 191170. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?191170

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How to Cite close
Sjöström, Johanna, and Mäkelä, Tomi(Sep 2006) Apoptosis and the Cell Cycle in Human Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006043]