Testicular Cancer

Abstract

Adult testicular germ cell tumors, although rare and curable, are an excellent model system for the study of mechanisms of germ cell transformation, chemotherapy sensitivity and resistance of tumors and regulation of embryonal lineage differentiation.

Keywords: germ cells; tumor; differentiation; chemotherapy sensitivity and resistance

Further Reading

Bosl GJ and Motzer RJ (1997) Testicular germ‐cell cancer. New England Journal of Medicine 337: 242–253.

Bourdon V, Naef F, Rao PH, et al. (2002) Genomic and expression analysis of the 12p11–12p12 amplicon in germ cell tumors using EST arrays identifies two novel amplified and over‐expressed genes. Cancer Research 62: 6281–6233.

Chaganti RSK and Houldsworth J (2000) Genetics and biology of human male germ cell tumors. Cancer Research 60: 1475–1482.

Heidenreich A, Srivastava S, Moul JW and Hofman R (2000) Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. European Urology 37: 121–135.

Horwich A (1996) Testicular Cancer – Investigation and Management. London, UK: Chapman & Hall.

Houldsworth J, Heath SC, Bosl GJ, Studer L and Chaganti RSK (2002) Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells. Cell Growth and Differentiation 13: 257–264.

Rajpert‐DeMeyts E, Grigor KM and Skakkebaek NE (1998) Neoplastic Transformation of Testicular Germ Cells. Copenhagen: Munksgaard.

Ulbright TM (1993) Germ cell neoplasms of the testis. American Journal of Surgical Pathology 17: 1075–1091.

Web Links

Cyclin D2 (CCND2); Locus ID: 894. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=894

Cyclin D2 (CCND2); MIM number: 123833. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?123833

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How to Cite close
Chaganti, RSK(Jan 2006) Testicular Cancer. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0006059]