Eugene V Koonin, National Center for Biotechnology Information, Bethesda, Maryland, USA
Published online: September 2006
DOI: 10.1002/9780470015902.a0006119
Comparative genomics has brought a new perspective to the origin and evolution of DNA repair. Evolution of repair is connected intimately to the evolution of replication systems but shows much greater plasticity as a result of many lineage-specific gene losses and horizontal gene-transfer events.
Keywords: DNA replication; horizontal gene transfer; lineage-specific gene loss; evolutionary plasticity
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