Dosage Compensation Mechanisms: Evolution


Degeneration of sex‐limited chromosomes favours the emergence of dosage compensation mechanisms able to equalize in both sexes the amount of products derived from sex‐linked genes. These mechanisms are understood in detail in the fly Drosophila melanogaster, the nematode Caenorhabditis elegans and in eutherian mammals. The three systems, biochemically and evolutionarily unrelated, share a common logic.

Keywords: chromosome degeneration; sex chromosomes; chromatin; transcription regulation; evolution


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Marín, Ignacio(Mar 2008) Dosage Compensation Mechanisms: Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006128.pub2]