Major Histocompatibility Complex (MHC) Genes: Polymorphism


The major histocompatibility complex (MHC) contains genes that code for glycoproteins that play key roles in the immune response. Several features of MHC gene polymorphism indicate that diversifying natural selection has acted upon these genes. Different models of diversifying selection may explain the observed variation.

Keywords: major histocompatibility complex; human leukocyte antigen; polymorphism; balancing selection


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Web Links

dbMHC. Anthropology populations

HLA‐A (major histocompatibility complex, class I, A); LocusID: 3105. Entrez Gene:

HLA‐A (major histocompatibility complex, class I, A); MIM number: 142800. OMIM:

HLA‐B (major histocompatibility complex, class I, B); LocusID: 3106. Entrez Gene:

HLA‐B (major histocompatibility complex, class I, B); MIM number: 142830. OMIM:

HLA‐DRB1 (major histocompatibility complex, class II, DR beta 1); LocusID: 3123. Entrez Gene:

HLA‐DRB1 (major histocompatibility complex, class II, DR beta 1); MIM number: 142857. OMIM:

HLA‐DQB1 (major histocompatibility complex, class II, DQ β); LocusID: 3119. Entrez Gene:

HLA‐DQB1 (major histocompatibility complex, class II, DQ β); MIM number: 604305. OMIM:

ImMunoGeneTics Database. A collection of high‐quality integrated databases specializing in immunoglobulins, T‐cell receptors and the MHC of all vertebrate species.

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Meyer, Diogo, and Mack, Steven J(Jul 2008) Major Histocompatibility Complex (MHC) Genes: Polymorphism. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006133.pub2]