Major Histocompatibility Complex (MHC) Genes: Polymorphism

Abstract

The major histocompatibility complex (MHC) contains genes that code for glycoproteins that play key roles in the immune response. Several features of MHC gene polymorphism indicate that diversifying natural selection has acted upon these genes. Different models of diversifying selection may explain the observed variation.

Keywords: major histocompatibility complex; human leukocyte antigen; polymorphism; balancing selection

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Further Reading

Frank SA (2002) Immunology and Evolution of Infectious Disease. Princeton, NJ: Princeton University Press.

Hansen JA (ed.) (2007) Immunobiology of the Human MHC. Proceedings of the 13th International Histocompatibility Workshop and Conference, Seattle: IHEG Press.

Kasahara M (ed.) (2000) Major Histocompatibility Complex; Evolution, Structure, and Function. Proceedings of the 6th International Workshop on MHC Evolution, Japan, Hayama.

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Web Links

dbMHC. Anthropology populations http://www.ncbi.nlm.nih.gov/gv/mhc/ihwg.cgi?ID=9&cmd=PRJOV

HLA‐A (major histocompatibility complex, class I, A); LocusID: 3105. Entrez Gene: http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=3105

HLA‐A (major histocompatibility complex, class I, A); MIM number: 142800. OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800

HLA‐B (major histocompatibility complex, class I, B); LocusID: 3106. Entrez Gene: http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=3106

HLA‐B (major histocompatibility complex, class I, B); MIM number: 142830. OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142830

HLA‐DRB1 (major histocompatibility complex, class II, DR beta 1); LocusID: 3123. Entrez Gene: http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=3123

HLA‐DRB1 (major histocompatibility complex, class II, DR beta 1); MIM number: 142857. OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142857

HLA‐DQB1 (major histocompatibility complex, class II, DQ β); LocusID: 3119. Entrez Gene: http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=3119

HLA‐DQB1 (major histocompatibility complex, class II, DQ β); MIM number: 604305. OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604305

ImMunoGeneTics Database. A collection of high‐quality integrated databases specializing in immunoglobulins, T‐cell receptors and the MHC of all vertebrate species. http://www.ebi.ac.uk/imgt/.

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How to Cite close
Meyer, Diogo, and Mack, Steven J(Jul 2008) Major Histocompatibility Complex (MHC) Genes: Polymorphism. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006133.pub2]