Proteases: Evolution


Human proteases have diverse fold structures, catalytic mechanisms, biochemical functions and evolutionary origins. Most arose by gene duplication, but some arose by horizontal transfer from prokaryotes. Adaptation and diversification of their biological roles have resulted from shifts in substrate specificities, expression patterns and new domain combinations.

Keywords: protease; evolution; gene duplication; domains; structure

Figure 1.

(a) Phylogram of HtrA proteases. (b) Human HtrA1 Q92743 domain and gene structure. (c) Human HtrA2 O43464 domain and gene structure. kb: kilobases; Mb: megabases.



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Web Links

European Bioinformatics Institute InterPro database. A resource for whole‐genome analysis

MEROPS Protease Database. A catalog and structure‐based classification of proteases, with additional information about them

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How to Cite close
Southan, Christopher(Apr 2008) Proteases: Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006141.pub2]