Gregory A Wray, Duke University, Durham, North Carolina, USA
Published online: December 2007
DOI: 10.1002/9780470015902.a0006142.pub2
Changes in transcriptional regulation can result from mutations in cis (within regulatory sequences) or trans (in the structure or expression of transcription factors). Modifications in transcription can have a profound impact on gene function and constitute an important class of evolutionary change within genomes.
Keywords: cis-regulatory sequence; enhancer; polymorphism; promoter; transcription factor
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| Further Reading | |
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