Exonic Splicing Enhancers

Alexei Fedorov, Harvard University, Cambridge, Massachusetts, USA
Larisa Fedorova, Tufts University, Boston, Massachusetts, USA

Published online: January 2006

DOI: 10.1038/npg.els.0006153

Exonic splicing enhancers (ESEs) are short motifs in exons that promote both constitutive and alternative splicing. Several splicing factors, known as SR proteins, bind specifically to ESEs during the initial steps of splicing to initiate assembly of the spliceosomal complex.

Keywords: alternative splicing; exon; intron; sequence motif; enhancer

 References
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Related Sub-Topics:

Nucleic Acid Structure | Translation and Protein synthesis | Protein Folding, Evolution and Degradation | Gene and Genome Structure and Organisation | RNA Structure and Function | DNA Structure and Function | Noncoding RNA | Posttranscriptional Modification
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Article Title: Exonic Splicing Enhancers
 
How to Cite close
Fedorov, Alexei, and Fedorova, Larisa(Jan 2006) Exonic Splicing Enhancers. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0006153]