Methylated DNA‐binding Proteins
Esteban Ballestar, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Manel Esteller, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Published online: January 2006
DOI: 10.1038/npg.els.0006157
Abstract
The information encoded by deoxyribonucleic acid methylation is interpreted by a family of proteins that share the methylated
CpG‐binding domain. These proteins are associated with histone deacetylase and mediate gene silencing through the modification
of chromatin.
Keywords: DNA methylation; gene repression; histone deacetylase; methylated CpG‐binding domain; methyl CpG binding protein 2
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Further Reading
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(2001)
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268: 1–6.
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DNA methylation patterns and epigenetic memory.
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Web Links
Structure Database of the NCBI
http://www.ncbi.nlm.nih.gov