Human Immunodeficiency Virus (HIV) Infection: Genetics


Host genes influence many aspects of the human immunodeficiency virus (HIV) from transmission and infection to disease progression and acquired immunodeficiency syndrome as well as responses to drugs and HIV vaccines.

Keywords: AIDS; HLA; chemokine; cytokine; host genes


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Kaslow RA, Carrington M, Apple R, et al. (1996) Influence of combinations of human major histocompatibility complex genes on the course of HIV‐1 infection. Nature Medicine 2: 405–411.

Kaslow RA, Rivers C, Tang J, et al. (2001) Polymorphisms in HLA class I genes associated with both favorable prognosis of HIV‐1 infection and positive cytotoxic T‐lymphocyte responses to ALVAC‐HIV recombinant canarypox vaccines. Journal of Virology 75: 8681–8689.

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Further Reading

Carrington M, Nelson G and O'Brien SJ (2001) Considering genetic profiles in functional studies of immune responsiveness to HIV‐1. Immunology Letters 79: 131–140.

Cooke GS and Hill AV (2001) Genetics of susceptibility to human infectious disease. Nature Reviews Genetics 2: 967–977.

Hill AVS (2001) The genomics and genetics of human infectious disease susceptibility. Annual Review of Genomics and Human Genetics 2: 373–400.

Kaslow RA and McNicholl JM (1999) Genetic determinants of HIV‐1 infection and its manifestations. Proceedings of the Association of American Physicians 111: 299–307.

Kostrikis LG (2000) Impact of natural chemokine receptor polymorphisms on perinatal transmission of human immunodeficiency virus type 1. Teratology 61: 387–390.

Web Links

Online Mendelian Inheritance in Man (OMIM)

ATP‐binding cassette, sub‐family B (MDR/TAP), member 1 (ABCB1); Locus ID: 5243. LocusLink:

Chemokine (C‐C motif) receptor 5 (CCR5); Locus ID: 1234. LocusLink:

Interleukin 1 receptor, type I (IL1R1); Locus ID: 3554. LocusLink:

Major histocompatibility complex, class I, B (HLA‐B); Locus ID: 3106. LocusLink:

Mannose‐binding lectin (protein C) 2, soluble (opsonic defect) (MBL2); Locus ID: 4153. LocusLink:

ATP‐binding cassette, sub‐family B (MDR/TAP), member 1 (ABCB1); MIM number: 171050. OMIM:‐post/Omim/dispmim?171050

Chemokine (C‐C motif) receptor 5 (CCR5); MIM number: 601373. OMIM:‐post/Omim/dispmim?601373

Interleukin 1 receptor, type I (IL1R1); MIM number: 147810. OMIM:‐post/Omim/dispmim?147810

Major histocompatibility complex, class I, B (HLA‐B); MIM number: 142830. OMIM:‐post/Omim/dispmim?142830

Mannose‐binding lectin (protein C) 2, soluble (opsonic defect) (MBL2); MIM number: 154545. OMIM:‐post/Omim/dispmim?154545

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McNicholl, Janet M, Lal, Renu B, and Kaslow, Richard(Sep 2006) Human Immunodeficiency Virus (HIV) Infection: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0006228]