Migraine: Genetics

Pasquale Montagna, University of Bologna Medical School, Bologna, Italy
Mirella Mochi, University of Bologna Medical School, Bologna, Italy

Published online: September 2006

DOI: 10.1002/9780470015902.a0006234

Migraine is a complex disease with multifactorial genetic determination. Disease risk is increased in relatives of migraine patients, and concordance rates are higher in monozygotic twins.

Keywords: migraine; genetics; familial hemiplegic migraine; linkage; association

Figure 1. Schematic drawing of CACNA1A with the original FHM, EA2 and SCA6 mutations (Ophoff et al., 1996; Zhuchenko et al., 1995).
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 References
    De Fusco M, Manconi R, Silvestri L, et al. (2003) Haploinsufficiency of the ATP1A2 encoding the Na+/K+ pump 2 subunit associated with familial hemiplegic migraine type 2. Nature Genetics. 2+subunit+associated+with+familial+hemiplegic+migraine+type+2%26JTL%3DNature+Genetics%26PYR%3D2003');
    Ducros A, Denier C, Joutel A, et al. (2001) The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. New England Journal of Medicine 345: 17–24.
    Ducros A, Joutel A, Vahedi K, et al. (1997) Mapping of a second locus for familial hemiplegic migraine to 1q21–q23 and evidence of further heterogeneity. Annals of Neurology 42: 885–890.
    Gardner K, Barmada MM, Ptacek LJ and Hoffman EP (1997) A new locus for hemiplegic migraine maps to chromosome 1q31. Neurology 49: 1231–1238.
    International Headache Society Headache Classification Committee (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8: 1–97.
    Joutel A, Bousser MG, Biousse V, et al. (1993) A gene for familial hemiplegic migraine maps to chromosome 19. Nature Genetics 5: 40–45.
    Montagna P (2000) Molecular genetics of migraine headaches: a review. Cephalalgia 20: 3–14.
    Ophoff RA, Terwindt GM, Vergouwe MN, et al. (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87: 543–552.
    Russell MB, Iselius L and Olesen J (1995) Investigation of inheritance of migraine by complex segregation analysis. Human Genetics 96: 726–730.
    Russell MB and Olesen J (1995) Increased familial risk and evidence of a genetic factor in migraine. British Medical Journal 31: 541–544.
    Zhuschenko O, Bailey J, Bonnen P, et al. (1997) Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel. Nature Genetics 15: 62–69.
 Further Reading
    Finnila S, Hassinen IE and Majamaa K (2001) Phylogenetic analysis of mitochondrial DNA in patients with an occipital stroke. Evaluation of mutations by using sequence data on the entire coding region. Mutation Research 458: 31–39.
    Gardner K (1999) The genetic basis of migraine: how much do we know? Canadian Journal of Neurological Science 26: 37–43.
    Kors EE, Haan J and Ferrari MD (1999) Genetics of primary headaches. Current Opinion in Neurology 12: 249–254.
    Lea RA, Shepherd AG, Curtain RP, et al. (2002) A typical migraine susceptibility region localizes to chromosome 1q31. Neurogenetics 4: 17–22.
    McCarthy LC, Hosford DA, Riley JH, et al. (2001) Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics 78: 135–149.
    Nyholt DR, Curtain RP and Griffiths LR (2000) Familial typical migraine: significant linkage and localization of a gene to Xq24–28. Human Genetics 107: 18–23.
    book Olesen J and Bousser MG (2000) "Genetics of headache disorders". Frontiers in Headache Research Series, vol. 8, pp. 1–288. Philadelphia, PA: Lippincott Williams and Wilkins.
    Terwindt GM, Ophoff RA, Haan J, et al. (1998) Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies. Dutch Migraine Genetics Research Group. European Journal of Human Genetics 6: 297–307.
    Tzourio C, El Amrani M, Poirier O, et al. (2001) Association between migraine and endothelin type A receptor (ETA-231 A/G) gene polymorphism. Neurology 56: 1273–1277.
    Ziegler DK, Hur YM, Bouchard Jr TJ, Hassanein RS and Barter R (1998) Migraine in twins raised together and apart. Headache 38: 417–422.

Related Sub-Topics:

Neurobiology of Disease | Molecular Genetics of Common and Complex Disease | Techniques and Tools in Clinical Genetics | Linkage Analysis
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Article Title: Migraine: Genetics
 
How to Cite close
Montagna, Pasquale, and Mochi, Mirella(Sep 2006) Migraine: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006234]