Migraine: Genetics


Migraine is a complex disease with multifactorial genetic determination. Disease risk is increased in relatives of migraine patients, and concordance rates are higher in monozygotic twins.

Keywords: migraine; genetics; familial hemiplegic migraine; linkage; association

Figure 1.

Schematic drawing of CACNA1A with the original FHM, EA2 and SCA6 mutations (Ophoff et al., ; Zhuchenko et al., ).



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Further Reading

Finnila S, Hassinen IE and Majamaa K (2001) Phylogenetic analysis of mitochondrial DNA in patients with an occipital stroke. Evaluation of mutations by using sequence data on the entire coding region. Mutation Research 458: 31–39.

Gardner K (1999) The genetic basis of migraine: how much do we know? Canadian Journal of Neurological Science 26: 37–43.

Kors EE, Haan J and Ferrari MD (1999) Genetics of primary headaches. Current Opinion in Neurology 12: 249–254.

Lea RA, Shepherd AG, Curtain RP, et al. (2002) A typical migraine susceptibility region localizes to chromosome 1q31. Neurogenetics 4: 17–22.

McCarthy LC, Hosford DA, Riley JH, et al. (2001) Single‐nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics 78: 135–149.

Nyholt DR, Curtain RP and Griffiths LR (2000) Familial typical migraine: significant linkage and localization of a gene to Xq24–28. Human Genetics 107: 18–23.

Olesen J and Bousser MG (2000) Genetics of headache disorders. Frontiers in Headache Research Series, vol. 8, pp. 1–288. Philadelphia, PA: Lippincott Williams and Wilkins.

Terwindt GM, Ophoff RA, Haan J, et al. (1998) Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies. Dutch Migraine Genetics Research Group. European Journal of Human Genetics 6: 297–307.

Tzourio C, El Amrani M, Poirier O, et al. (2001) Association between migraine and endothelin type A receptor (ETA‐231 A/G) gene polymorphism. Neurology 56: 1273–1277.

Ziegler DK, Hur YM, Bouchard Jr TJ, Hassanein RS and Barter R (1998) Migraine in twins raised together and apart. Headache 38: 417–422.

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How to Cite close
Montagna, Pasquale, and Mochi, Mirella(Sep 2006) Migraine: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006234]