Maj Hultén, University of Warwick, Coventry, UK
Charles Tease, University of Warwick, Coventry, UK
Published online: September 2006
DOI: 10.1002/9780470015902.a0006268
Two general approaches are available for investigating patterns of meiotic recombination in human germ cells: firstly, direct cytogenetic assessment of recombination in the cells in which it occurs; secondly, indirect genetic methods that exploit DNA polymorphisms. Each of these approaches has advantages and disadvantages for the production of genetic recombination maps.
Keywords: meiotic recombination; crossover; MLH1 foci; chiasmata; linkage analysis; map function; interference
| References | |
| Barlow AL and Hultén MA (1998) Crossing over analysis at pachytene in man. European Journal of Human Genetics 6: 350–358. | |
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| Hultén MA (1994) Chiasma formation, crossing-over and recombination in meiosis. Trends in Genetics 10: 112–113. | |
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| Further Reading | |
| book Bishop D (2001) "Meiotic recombination pathways". Encyclopedia of Life Sciences, http://www.els.net, London: Nature Publishing Group. | |
| DeWan AT, Parrado AR, Marise TC and Leal SM (2002) The map problem: a comparison of genetic and sequence-based physical maps. American Journal of Human Genetics 70: 101–107. | |
| Hassold T, Sherman S and Hunt P (2000) Counting cross-overs: characterizing meiotic recombination in mammals. Human Molecular Genetics 9: 2409–2419. | |
| Hultén MA and Lawrie NM (1993) Chiasma density and interference maps of the normal and translocated chromosome 9 in the human male. First International Workshop on Chromosome 9. Annals of Human Genetics 56: 194–195. | |
| Hultén MA, Palmer RW and Laurie DA (1982) Chiasma derived genetic maps and recombination fractions: chromosome 1. Annals of Human Genetics 46: 167–175. | |
| Jorde LB (2000) Linkage disequilibrium and the search for complex diseases. Genome Research 10: 1435–1444. | |
| Laurie DA, Palmer RW and Hultén MA (1982) Chiasma derived genetic lengths and recombination fractions: chromosomes 2 and 9. Annals of Human Genetics 46: 233–244. | |
| Lichten M and Goldman ASH (1995) Meiotic recombination hotspots. Annual Review of Genetics 29: 423–444. | |
| Petes TH (2001) Meiotic recombination hot spots and cold spots. Nature Reviews Genetics 2: 369. | |
| Saadallah N and Hultén MA (1983) Chiasma distribution, genetic lengths and recombination fractions: a comparison between chromosome 15 and 16. Journal of Medical Genetics 20: 362. | |
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