deCODE: A Genealogical Approach to Human Genetics in Iceland

Abstract

The identification of genes contributing to diseases provides the most direct method for discovering the rate‐limiting molecular pathways involved in their pathogenesis. deCODE has built a system of information in Iceland, linking medical information from patients who have given them specific informed consent, disease by disease, to a nation‐wide genealogy database and their molecular genetic information.

Keywords: genealogy; Iceland; genetics; common disease; genotype

References

Gretarsdottir S, Sveinbjartsdottir S, Jonsson H, et al. (2002) Localization of a susceptibility gene for common forms of stroke to 5q12. American Journal of Human Genetics 70: 593–603.

Gudbjartsson DF, Jonasson K, Frigge ML and Kong A (2000) Allegro, a new computer program for multipoint linkage analysis. Nature Genetics 25: 12–13.

Gulcher JR, Kong A and Stefansson K (2001a) The role of linkage studies for common diseases. Current Opinion in Genetics and Development 11: 264–267.

Gulcher J, Kong A and Stefansson K (2001b) The genealogic approach to human genetics of disease. Cancer Journal 7: 61–68.

Gulcher JR, Kristjansson K, Gudbjartsson H and Stefansson K (2000) Protection of privacy by third‐party encryption in genetic research in Iceland. European Journal of Human Genetics 8: 739–742.

Kong A, Gudbjartsson DF, Sainz J, et al. (2002) A high‐resolution recombination map of the human genome. Nature Genetics 31: 241–247.

Stefansson H, Sigurdsson E, Steinsthorsdottir V, et al. (2002a) Neuregulin 1 and susceptibility to schizophrenia. American Journal of Human Genetics 71: 877–892.

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Further Reading

Gretarsdottir S, Thorleifsson G, Reynirsdottir S, et al. Phosphodiesterase 4D gene polymorphisms confer risk to ischemic stroke (submitted).

Styrkarsdottir U, Cazier JB, Rolfsson O, et al. The Bone Morphogenetic Protein 2 gene contributes to bone mass density and osteoporotic fractures (submitted).

Web Links

deCODE genetics. Website for Decode Genetics describing the company, the diseases of interest and population based genetics platform http://www.decode.com/

BMP2 (bone morphogenetic protein 2); Locus ID: 650. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=650

NRG1 (neuregulin 1); Locus ID: 3084. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3084

PDE4D (phosphodiesterase 4D, cAMP‐specific (phosphodiesterase E3 dunce homolog, Drosophila)); Locus ID: 5144. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5144

BMP2 (bone morphogenetic protein 2); MIM number: 112261. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?112261

NRG1 (neuregulin 1); MIM number: 142445. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?142445

PDE4D (phosphodiesterase 4D, cAMP‐specific (phosphodiesterase E3 dunce homolog, Drosophila)); MIM number: 600129. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600129

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How to Cite close
Gulcher, Jeffrey R, and Stefansson, Kari(Sep 2006) deCODE: A Genealogical Approach to Human Genetics in Iceland. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0006270]