Zhigang Tian, University of Science and Technology of China, Anhui, China
Cai Zhang, Shandong University, Shandong, China
Published online: April 2007
DOI: 10.1002/9780470015902.a0020179
Natural killer (NK) cell effector functions are regulated by integrated signals across the array of stimulatory and inhibitory receptors engaged upon interaction with target cell surface ligands. A delicate balance between activating and inhibiting receptors determines the outcome of NK cell activation.
Keywords: NK cell receptor; innate immunity; tumour; viral infection; immune surveillance
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| Further Reading | |
| Bottino C, Castriconi R, Moretta L and Morretta A (2005) Cellular ligands of activating NK receptors. Trends of Immunology 26: 221–226. | |
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| Long EO and Rajagopalan S (2002) Stress signals activate natural killer cells. Journal of Experimental Medicine 196: 1399–1402. | |
| Moretta L, Bottino C, Pende D et al. (2006) Surface NK receptors and their ligands on tumor cells. Seminars in Immunology 18(3): 151–158. | |
| Moretta L and Moretta A (2004) Unravelling natural killer cell function: triggering and inhibitory human NK receptors. The EMBO Journal 23: 255–259. | |
| Orange JS, Fassett MS, Koopman LA et al. (2002) Viral evasion of natural killer cells. Nature Immunology 3(11): 1006–1012. | |
| Ortaldo JRand Young HA (2005) Mouse Ly49 NK receptors: balancing activation and inhibition. Molecular Immunology 42(2): 445–450. | |
| Rajagopalan S and Long EO (2005) Viral evasion of NK-cell activation. Trends of Immunology 26(8): 403–405. | |
| Raulet DH (2003) Roles of the NKG2D immunoreceptor and its ligands. Nature Reviews of Immunology 3(10): 781–790. | |
| Watzl C (2003) The NKG2D receptor and its ligands–recognition beyond the missing self? Microbes and Infection 5: 31–37. | |
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