Julius Clemence R Hafalla, London School of Hygiene and Tropical Medicine, London, UK
Kai Matuschewski, Heidelberg University School of Medicine, Heidelberg, Germany
Ann‐Kristin Mueller, London School of Hygiene and Tropical Medicine, London, UK
Published online: December 2007
Malaria, a vector‐borne disease caused by Plasmodium parasites, remains a major cause of morbidity and mortality in the developing world. To attain a substantial and steady decline
in disease and deaths, a safe and efficacious vaccine is an indispensable tool. However, fundamental to the discovery, design
and development of a malaria vaccine is a comprehensive knowledge of the induction and regulation of protective immune responses
against the parasite. To this end, studies utilizing animal models, naïve human volunteers and individuals living in malaria
endemic areas have provided important insights regarding the different mechanisms of antimalaria immunity.
Keywords: malaria; Plasmodium; immunity; protection; vaccine
McGregor IA and
Gamma‐globulin and acquired immunity to human malaria.
Tanner M and
Malaria: burden of disease.
Current Molecular Medicine
Cockburn IA and
Protective and pathogenic roles of CD8+ T cells during malaria infection.
Boscardin S et al.
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites.
Kappe SHI and
Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.
Most H and
Protective immunity produced by the injection of x‐irradiated sporozoites of Plasmodium berghei.
Hannan CM et al.
Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T‐cell priming.
Hirunpetcharat C et al.
Immunity to malaria after administration of ultra‐doses of red cells infected with Plasmodium falciparum.
Gothard PK et al.
A CD4+ T‐cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.
Turner L et al.
Evidence for the involvement of VAR2CSA in pregnancy‐associated malaria.
Journal of Experimental Medicine
Ferreira A et al.
Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites.
Nussenzweig V and
Hybridoma produces antibodies directed against the sporozoite stage of malaria parasite.
Anstey NM and
de Souza JB
Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination.
Current Topics in Microbiology and Immunology
Marsh K and
Immune effector mechanisms in malaria.
Vaccine development against malaria.
Current Opinion in Immunology
Stevenson MM and
Innate immunity to malaria.
Nature Review of Immunology
Combes V and
Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion.
Annals of the New York Academy of Science