Susceptibility to Malaria, Genetics of


Malaria has exerted a strong, selective pressure on many genes in the human genome, leading to the development and retention of several alleles which confer a proctective advantage against blood‐stage infection. Many of these polymorphisms, including sickle cell anaemia and the thalassaemias, are in the haemoglobin genes, but other mutations have been found in metabolism and immune response. Since many interacting genes are involved in the host response to malaria, animal models have been extremely useful in helping to identify and understand the host–parasite interaction.

Keywords: malaria; genetics; infectious disease; plasmodium; haemoglobin


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Further Reading

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Berghout, Joanne, and Gros, Philippe(Jul 2007) Susceptibility to Malaria, Genetics of. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0020218]