Susceptibility to Malaria, Genetics of

Abstract

Malaria has exerted a strong, selective pressure on many genes in the human genome, leading to the development and retention of several alleles which confer a proctective advantage against blood‐stage infection. Many of these polymorphisms, including sickle cell anaemia and the thalassaemias, are in the haemoglobin genes, but other mutations have been found in metabolism and immune response. Since many interacting genes are involved in the host response to malaria, animal models have been extremely useful in helping to identify and understand the host–parasite interaction.

Keywords: malaria; genetics; infectious disease; plasmodium; haemoglobin

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Further Reading

Kwiatkowski DP (2005) How malaria has affected the human genome and what human genetics can teach us about malaria. American Journal of Human Genetics 77(2): 171–192.

Hill AV (2001) The genomics and genetics of infectious disease susceptibility. Annual Reviews of Genomics and Human Genetics 2: 373–400.

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How to Cite close
Berghout, Joanne, and Gros, Philippe(Jul 2007) Susceptibility to Malaria, Genetics of. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0020218]