Actinobacteria

Actinobacteria are Gram-positive bacteria with a high mol% G+C composition, widely distributed in soil where they play an important part in the decomposition of organic matter. These bacteria are responsible for the distinctive scent of freshly exposed, moist soil. Actinobacteria are morphologically diverse ranging from coccoid, fragmenting hyphal forms to those with a highly differentiated branched mycelium. Many of these bacteria also produce external spores. Several actinobacteria are important human, animal and plant pathogens. However, they are major producers of medically important antibiotics, especially members of the genus Streptomyces, the most abundant group.

Keywords: actinobacteria; actinomycetes; classification; Streptomyces; secondary metabolites

Figure 1. Morphological diversity found in the phylum Actinobacteria. (a) Nocardia sp.; (b) Streptomyces sp. producing a secondary metabolite (droplets); (c) Micromonospora sp.; (d, e) Streptomyces sp.; (f) Actinomadura sp.; (g) edge of a streptomycete colony producing an antibiotic and (h) Micromonospora sp. Figures 1b, 1e and 1g are picture courtesy of Dr Ramón Santamaria.
Figure 2. Steps involved in the life cycle of a filamentous actinobacterium. Modified from Kieser T et al. (2000) Practical Streptomyces Genetics. Crowes, England, John Innes Foundation.
Figure 3. Phylogenetic tree of 16S rRNA sequences of selected actinobacterial species.
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 Further Reading
    book Beaman BL, Saubolle MA and Wallace RJ (1995) "Nocardia, Rhodococcus, Streptomyces, Oerskovia, and other aerobic actinomycetes of medical importance". In: Murray PR (Ed.) Manual of Clinical Microbiology, 6th edn. pp. 379–399. Washington, DC: American Society for Microbiology.
    Embley MT and Stackebrandt E (1994) The molecular phylogeny and systematics of actinomycetes. ASM News 60: 366–369.
    book Falkow S, Rosenberg E, Schleifer KH and Stackebrandt E (eds) (2006) The Propkaryotes, 3rd edn, Volume 3: Archaea. Bacteria: Firmicutes, Actinomycetes New York: Springer.
    other Garrity GM, Bell JA and Lilburn TG (2004) Taxonomic Outline of the Prokaryotes. Bergey's Manual of Systematic Bacteriology, 2nd edn DOI:10.1007/bergeyoutline200405.
    Guarner F and Malagelada JR (2003) Gut flora in health and disease. The Lancet 361: 512–519.
    Jensen PR, Mincer TJ, Williams PG and William F (2005) Marine actinomycete diversity and natural product discovery. Antonie van Leeuwenhoek 87: 43–48.
    book Kieser T, Bibb MJ, Buttner MJ, Clater KF and Hopwood DA (2000) Practical Streptomyces Genetics. Crowes, England: John Innes Foundation.
    Lazzarini A, Cavaletti L, Toppo G and Marinelli F (2000) Rare genera of actinomycetes as potential producers of new antibiotics. Antonie van Leeuwenhoek 78: 399–405.
    book Lengeler J, Drews G and Schlegel HG (eds) (1999) Biology of Prokaryotes. Stuttgart: Georg Thieme Verlag.
    book Madigan MT, Martinko JM, Dunlap PV and Clark DP (2006) Brock Biology of Microorganisms, 11th edn. San Francisco: Benjamin Cummings.
    book Perry JJ, Staley JT and Lory S (2003) Microbial Life. Sunderland, MA: Sinauer Associates.
    book Prescott L, Harley J and Klein D (2002) Microbiology, 5th edn. Boston: McGraw Hill.
    Schaberg T (1996) Epidemiology of tuberculosis in Europe: still a matter of deep concern. European Respiratory Journal 9: 866–867.
    Stackebrandt E, Rainey FA and Ward-Rainey NL (1997) Proposal for a new hierarchic classification system, Actinobacteria classis nov. International Journal of Systematic Bacteriology 47: 479–491.
    Vera-Cabrera L, Ochoa-Felix EY, Gonzalez G et al. (2004) In vitro activities of new quinolones and oxazolidinones against Actinomadura madurae. Antimicrobial Agents and Chemotherapy 48: 1037–1039.
    book Williams ST, Lanning S and Wellington EMH (1984) "Ecology of Actinomycetes". In: Goodfellow M, Mordaski M and Williams ST (eds) The Biology of Actinomycetes, pp. 481–528. London: Academic Press.
    book Williams ST, Sharpe ME and Holt JG (eds) (1989) Bergey's Manual of Systematic Bacteriology, 1st edn, vol 4. New York: Springer.
 Electronic resources
    ePath Bacterial (Prokaryotic) Phylogeny Webpage (2006) Phylogeny and Protein Signatures for Actinobacteria (High G+C Gram-Positive), March. http://www.bacterialphylogeny.info/groupspecific/actinobacteria/actinobacteria.html
    ePath Euzéby J (2007) List of prokaryotic names with standing in nomenclature. http://www.bacterio.cict.fr
    ePath Retrieval system used at NCBI for the major databases, including PubMed, Nucleotide and Protein Sequences, Protein Structures, Complete Genomes, Taxonomy, and others. http://www.ncbi.nlm.nih.gov
    ePath Young JM, Bull CT, De Boer SH et al. Names of plant pathogenic bacteria. http://www.isppweb.org/names_bacterial_revised.asp
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How to Cite close
Trujillo, Martha E(Jul 2008) Actinobacteria. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0020366]