Viral Vectors for Gene Therapy
Nicola J Philpott, University College London, London, UK
Published online: September 2007
DOI: 10.1002/9780470015902.a0020707
Abstract
Viruses can be engineered to deliver genetic material to cells without causing disease. Viral gene therapy vectors have therapeutic
use in the treatment of hereditary disease, infectious diseases and cancer as well as for vaccine development.
Keywords: retrovirus; lentivirus; adenovirus; adeno‐associated virus
References
Boulaiz H,
Marchal JA,
Prados J,
Melguizo C and
Aranega A
(2005)
Non‐viral and viral vectors for gene therapy.
Cellular and Molecular Biology (Noisy‐le‐grand, France)
51(1): 3–22.
Hacein‐Bey‐Abina S,
Le Deist F,
Carlier F et al.
(2002)
Sustained correction of X‐linked severe combined immunodeficiency by ex vivo gene therapy.
New England Journal of Medicine
346(16): 1185–1193.
Humeau LM,
Binder GK,
Lu X et al.
(2004)
Efficient lentiviral vector‐mediated control of HIV‐1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load.
Molecular Therapy
9(6): 902–913.
Kay MA,
Manno CS,
Ragni MV et al.
(2000)
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.
Nature Genetics
24(3): 257–261.
Kohn DB,
Sadelain M and
Glorioso JC
(2003)
Occurrence of leukaemia following gene therapy of X‐linked SCID.
Nature Reviews Cancer
3(7): 477–488.
McCormick F
(2001)
Cancer gene therapy: fringe or cutting edge?
Nature Reviews Cancer
1(2): 130–141.
Naldini L,
Blomer U,
Gallay P et al.
(1996)
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.
Science
272(5259): 263–267.
Schroder AR,
Shinn P,
Chen H et al.
(2002)
HIV‐1 integration in the human genome favors active genes and local hotspots.
Cell
110(4): 521–529.
Yanez‐Munoz RJ,
Balaggan KS,
MacNeil A et al.
(2006)
Effective gene therapy with non‐integrating Lentiviral vectors.
Nature Medicine.
Further Reading
Bernard NF,
David MK,
Peter MH et al.
(2007)
Fields Virology.
Lippincott Williams & Wilkins.