An Evolutionary Framework for Common Disease


Susceptibility alleles for common diseases are a subset of all natural genetic variation; as such they are jointly shaped by random drift and natural selection. Computer simulation and empirical studies show that models of purifying selection and adaptive evolution apply to risk alleles for common diseases. These models have important implications for the design of diseaseā€mapping studies.

Keywords: disease association studies; allele frequency spectrum; genetic variation; natural selection


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Luca, Francesca, and Di Rienzo, Anna(Dec 2007) An Evolutionary Framework for Common Disease. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0020758]