Rapidly Evolving Regions of the Human Genome

Abstract

Rapidly evolving genes are those genes that exhibit accelerated rates of nonsynonymous substitutions between species, i.e. the number of nonsynonymous substitutions per nonsynonymous site (amino acid altering) significantly exceeds the number of synonymous substitutions per synonymous site.

Keywords: rapid evolution; positive selection; synonymous substitution; reproductive proteins; nervous system and human accelerated region

Figure 1.

The type of methods used to detect the signatures of rapid evolution, functional categories of genes bearing evidence of action and the advantages of mapping rapid evolution.

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References

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Further Reading

Swanson WJ and Vacquier VD (2002) The rapid evolution of reproductive proteins. Nature Reviews Genetics 3: 137–144.

Tang K, Thornton KR and Stoneking M (2007) A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biology 5: e171.

Vallender EJ and Lahn BT (2004) Positive selection on the human genome. Human Molecular Genetics 13(2): R245–R254.

Voight BF, Kudaravalli S, Wen X and Pritchard JK (2006) A map of recent positive selection in the human genome. PLoS Biology 4: e72.

Wagner A (2007) Rapid detection of positive selection in genes and genomes through variation clusters. Genetics 176: 2451–2463.

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How to Cite close
Agarwal, Subhash Mohan(Jul 2008) Rapidly Evolving Regions of the Human Genome. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0020802]