Molecular Clocks: Determining the Age of the Human–Chimpanzee Divergence

The approximate clocklike nature of the accumulation of nucleotide substitutions (the ‘molecular clock’) allows for the estimation of the time of divergence between modern species, dependent on calibrating the clock with known divergence dates from the fossil record. The molecular clock gives dates of approximately 6–8 million years ago for the human–chimpanzee divergence, in general agreement with the palaeontological evidence.

Keywords: molecular clock; human evolution; hominin; hominid; divergence

Figure 1. Estimating the time of divergence between human and chimpanzee relies on a calibration based on a known divergence time – in this case either the hominine–pongine split or the hominoid–cercopithecoid split. Note the taxonomy used herein.
Figure 2. Hypothetical species divergence leading to extant taxa (species 1–3) and fossils used to date the calibration node (A–E).
Figure 3. The current state of knowledge regarding the hominin fossil record (left) surrounding the human–chimpanzee divergence, compared to divergence dates from molecular data (right). Fossil species are taken from Wood (2006), references therein, and the more recent primary literature. Molecular dates are largely taken from Steiper and Young (2006, p. 390 their Table 4), removing dates not based on DNA sequence data, and adding the dates from Hasegawa et al. (1985) and Patterson et al. (2006). Open circles represent divergence dates as estimated in the original publications (or means if ranges were given); closed circles are the same dates standardized by assuming a 30.5-Mya divergence between hominoids and cercopithecoids or an 18.3-Mya divergence between humans and orangutans (Steiper and Young, 2006).
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 References
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 Further Reading
    Donoghue PCJ and Benton MJ (2007) Rocks and clocks: calibrating the Tree of Life using fossils and molecules. Trends in Ecology and Evolution 22: 424–431.
    Elango N, Thomas JW, NISC Comparative Sequencing Program, Yi SV (2006) Variable molecular clocks in hominoids. Proceedings of the National Academy of Sciences of the USA 103: 1370–1375.
    Steiper ME, Young NM and Sukarna TY (2004) Genomic data support the hominoids slowdown and an Early Oligocene estimate for the hominoid-cercopithecoid divergence. Proceedings of the National Academy of Sciences of the USA 101: 17021–17026.
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Jensen‐Seaman, Michael I, and Hooper‐Boyd, Kathryn A(May 2008) Molecular Clocks: Determining the Age of the Human–Chimpanzee Divergence. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0020813]