References
Auton A,
Fledel‐Alon A,
Pfeifer S et al.
(2012)
A fine‐scale chimpanzee genetic map from population sequencing.
Science
336(6078):
193–198.
Barlow AL and
Hultén MA
(1998)
Crossing over analysis at pachytene in man.
European Journal of Human Genetics
6(4):
350–358.
Baudat F,
Buard J,
Grey C et al.
(2010)
PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.
Science
327(5967):
836–840.
Berg IL,
Neumann R,
Lam KW et al.
(2010)
PRDM9 variation strongly influences recombination hot‐spot activity and meiotic instability in humans.
Nature Genetics
42(10):
859–863.
Botstein D,
White RL,
Skolnick M and
Davis RW
(1980)
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
American Journal of Human Genetics
32(3):
314–331.
Broman KW,
Murray JC,
Sheffield VC,
White RL and
Weber JL
(1998)
Comprehensive human genetic maps: individual and sex‐specific variation in recombination.
American Journal of Human Genetics
63(3):
861–869.
Charlesworth B
(2012)
The effects of deleterious mutations on evolution at linked sites.
Genetics
190(1):
5–22.
Cheung VG,
Burdick JT,
Hirschmann D and
Morley M
(2007)
Polymorphic variation in human meiotic recombination.
American Journal of Human Genetics
80:
526–530.
Coop G,
Wen X,
Ober C,
Pritchard JK and
Przeworski M
(2008)
High‐resolution mapping of crossovers reveals extensive variation in fine‐scale recombination patterns among humans.
Science
319(5868):
1395–1398.
Daly MJ,
Rioux JD,
Schaffner SF,
Hudson TJ and
Lander ES
(2001)
High‐resolution haplotype structure in the human genome.
Nature Genetics
29(2):
229–232.
Dib C,
Fauré S,
Fizames C et al.
(1996)
A comprehensive genetic map of the human genome based on 5,264 microsatellites.
Nature
380(6570):
152–154.
Dorus S,
Vallender EJ,
Evans PD et al.
(2004)
Accelerated evolution of nervous system genes in the origin of Homo sapiens.
Cell
119(7):
1027–1040.
Dumont BL and
Payseur BA
(2008)
Evolution of the genomic rate of recombination in mammals.
Evolution
62(2):
276–294.
Fledel‐Alon A,
Wilson DJ,
Broman K, et al.
(2009)
Broad‐scale recombination patterns underlying proper disjunction in humans.
PLoS Genetics
5(9):
e1000658.
Freudenberg J,
Fu YH and
Ptacek LJ
(2007)
Enrichment of HapMap recombination hotspot predictions around human nervous system genes: evidence for positive selection?
European Journal of Human Genetics
15(10):
1071–1078.
Galtier N and
Duret L
(2007)
Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution.
Trends in Genetics
23(6):
273–277.
Hellmann I,
Prüfer K,
Ji H et al.
(2005)
Why do human diversity levels vary at a megabase scale?
Genome Research
15(9):
1222–1231.
Hill WG and
Robertson A
(1966)
The effect of linkage on limits to artificial selection.
Genetics Research
8(3):
269–294.
Ijdo JW,
Baldini A,
Ward DC,
Reeders ST and
Wells RA
(1991)
Origin of human chromosome 2: an ancestral telomere‐telomere fusion.
Proceedings of the National Academy of Sciences of the USA
88(20):
9051–9055.
International Chimpanzee Sequencing and Analysis Consortium
(2005)
Initial sequence of the chimpanzee genome and comparison with the human genome.
Nature
437(7055):
69–87.
International HapMap Consortium
(2007)
A second generation human haplotype map of over 3.1 million SNPs.
Nature
449:
851–861.
International Human Genome Sequencing Consortium
(2001)
Initial sequencing and analysis of the human genome.
Nature
409(6822):
860–921.
Jeffreys AJ,
Kauppi L and
Neumann R
(2001)
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex.
Nature Genetics
29(2):
217–222.
Jeffreys AJ and
Neumann R
(2002)
Reciprocal crossover asymmetry and meiotic drive in a human recombination hot spot.
Nature Genetics
31(3):
267–271.
Keightley PD and
Otto SP
(2006)
Interference among deleterious mutations favours sex and recombination in finite populations.
Nature
443(7107):
89–92.
Kong A,
Barnard J,
Gudbjartsson DF et al.
(2004)
Recombination rate and reproductive success in humans.
Nature Genetics
36(11):
1203–1206.
Kong A,
Gudbjartsson DF,
Sainz J et al.
(2002)
A high‐resolution recombination map of the human genome.
Nature Genetics
31(3):
241–247.
Kong A,
Thorleifsson G,
Gudbjartsson DF et al.
(2010)
Fine‐scale recombination rate differences between sexes, populations and individuals.
Nature
467(7319):
1099–1103.
Kong A,
Thorleifsson G,
Stefansson H et al.
(2008)
Sequence variants in the RNF212 gene associate with genome‐wide recombination rate.
Science
319(5868):
1398–1401.
Kostka D,
Hubisz MJ,
Siepel A and
Pollard KS
(2012)
The role of GC‐biased gene conversion in shaping the fastest evolving regions of the human genome.
Molecular Biology and Evolution
29(3):
1047–1057.
Lenzi ML,
Smith J,
Snowden T et al.
(2005)
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes.
American Journal of Human Genetics
76(1):
112–127.
Lercher MJ and
Hurst LD
(2002)
Human SNP variability and mutation rate are higher in regions of high recombination.
Trends in Genetics
18(7):
337–340.
Li W and
Freudenberg J
(2009)
Two‐parameter characterization of chromosome‐scale recombination rate.
Genome Research
19(12):
2300–2307.
Mather K
(1937)
Crossing over.
Biological Reviews of the Cambridge Philosophical Society
13:
258–292.
Meyer M,
Kircher M,
Gansauge MT et al.
(2012)
A high‐coverage genome sequence from an archaic Denisovan individual.
Science
338(6104):
222–226.
Morgan TH,
Sturtevant AH,
Muller HJ and
Bridge CB
(1915)
The Mechanism of Mendelian Heredity.
New York: Henry Holt.
Muller HJ
(1931)
Some genetic aspects of sex.
American Naturalist
66(703):
118–138.
Muller HJ
(1964)
The relation of recombination to mutational advance.
Mutation Research
1:
2–9.
Myers S,
Bottolo L,
Freeman C,
McVean G and
Donnelly P
(2005)
A fine‐scale map of recombination rates and hotspots across the human genome.
Science
310(5746):
321–324.
Myers S,
Bowden R,
Tumian A et al.
(2010)
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
Science
327(5967):
876–879.
Nachman MW
(2001)
Single nucleotide polymorphisms and recombination rate in humans.
Trends in Genetics
17(9):
481–485.
Necsulea A,
Sémon M,
Duret L and
Hurst LD
(2009)
Monoallelic expression and tissue specificity are associated with high crossover rates.
Trends in Genetics
25(12):
519–522.
Pardo‐Manuel de Villena F and
Sapienza C
(2001)
Recombination is proportional to the number of chromosome arms in mammals.
Mammalian Genome
12(4):
318–322.
Parvanov ED,
Petkov PM and
Paigen K
(2010)
Prdm9 controls activation of mammalian recombination hotspots.
Science
327(5967):
835.
Ptak SE,
Hinds DA,
Koehler K et al.
(2005)
Fine‐scale recombination patterns differ between chimpanzees and humans.
Nature Genetics
37(4):
429–434.
Reich DE,
Schaffner SF,
Daly MJ et al.
(2002)
Human genome sequence variation and the influence of gene history, mutation and recombination.
Nature Genetics
32(1):
135–142.
Rice WR and
Chippindale AK
(2001)
Sexual recombination and the power of natural selection.
Science
294(5542):
555–559.
Sandovici I,
Kassovska‐Bratinova S,
Vaughan JE et al.
(2006)
Human imprinted chromosomal regions are historical hot‐spots of recombination.
PLoS Genetics
2(7):
e101.
Spencer CC,
Deloukas P,
Hunt S et al.
(2006)
The influence of recombination on human genetic diversity.
PLoS Genetics
2(9):
e148.
Thomas JH,
Emerson RO and
Shendure J
(2009)
Extraordinary molecular evolution in the PRDM9 fertility gene.
PLoS One
4(12):
e8505.
Winckler W,
Myers SR,
Richter DJ et al.
(2005)
Comparison of fine‐scale recombination rates in humans and chimpanzees.
Science
308(5718):
107–111.
Further Reading
Clark AG,
Wang X and
Matise T
(2010)
Contrasting methods of quantifying fine structure of human recombination.
Annual Review of Genomics and Human Genetics
11:
45–64.
Coop G and
Przeworski M
(2007)
An evolutionary view of recombination. Nature Reviews.
Genetics
8:
23–34.
Lynn A,
Ashley and
Hassold T
(2004)
Variation in human meiotic recombination.
Annual Review of Genomics and Human Genetics
5:
317–349.
McVean G
(2010)
What drives recombination hotspots to repeat DNA in humans?
Philosophical Transactions of the Royal Society B: Biological Sciences
365(1544):
1213–1218.
Paigen K and
Petkov P
(2010)
Mammalian recombination hot spots: properties, control and evolution.
Nature Reviews Genetics
11(3):
221–233.
Ponting CP
(2011)
What are the genomic drivers of the rapid evolution of PRDM9?
Trends in Genetics
27(5):
165–171.
Rice WR
(2002)
Experimental tests of the adaptive significance of sexual recombination.
Nature Reviews Genetics
3:
241–251.
Smukowski CS and
Noor MA
(2011)
Recombination rate variation in closely related species.
Heredity
107(6):
496–508.
Stumpf MP and
McVean G
(2003)
Estimating recombination rates from population genetic data.
Nature Reviews Genetics
4:
959–968.
Webster MT and
Hurst LD
(2012)
Direct and indirect consequences of meiotic recombination: implications for genome evolution.
Trends in Genetics
28(3):
101–109.