| References |
|
|
Arnold SA and
Brekken RA
(2009)
SPARC: a matricellular regulator of tumorigenesis.
Journal of Cell Communication and Signaling
3:
255–273.
|
|
|
Baena-Lopez LA,
Rodriguez I and
Baonza A
(2008)
The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally like.
Proceedings of the National Academy of Sciences of the USA
105:
9645–9650.
|
|
|
Bangi E,
Pitsouli C,
Rahme LG,
Cagan R and
Apidianakis Y
(2012)
Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells.
EMBO Reports
13:
569–576.
|
|
|
Beaucher M,
Goodliffe J,
Hersperger E et al.
(2007a)
Drosophila brain tumor metastases express both neuronal and glial cell type markers.
Developmental Biology
301:
287–297.
|
|
|
Beaucher M,
Hersperger E,
Page-McCaw A and
Shearn A
(2007b)
Metastatic ability of Drosophila tumors depends on MMP activity.
Developmental Biology
303:
625–634.
|
|
|
de Beco S,
Ziosi M and
Johnston LA
(2012)
New frontiers in cell competition.
Developmental Dynamics
241:
831–841.
|
|
|
Berger C,
Harzer H,
Burkard TR et al.
(2012)
FACS purification and transcriptome analysis of Drosophila neural stem cells reveals a role for klumpfuss in self-renewal.
Cell Reports
2:
407–418.
|
|
|
Bonavia R,
Inda MM,
Cavenee WK and
Furnari FB
(2011)
Heterogeneity maintenance in glioblastoma: a social network.
Cancer Research
71:
4055–4060.
|
|
|
Bossuyt W,
De Geest N,
Aerts S et al.
(2009a)
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.
PLoS Biology
7:
e40.
|
|
|
Bossuyt W,
Kazanjian A,
De Geest N et al.
(2009b)
Atonal homolog 1 is a tumor suppressor gene.
PLoS Biology
7:
e39.
|
|
|
Brumby AM,
Goulding KR,
Schlosser T et al.
(2011)
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.
Genetics
188:
105–125.
|
|
|
Brumby AM and
Richardson HE
(2005)
Using Drosophila melanogaster to map human cancer pathways.
Nature Reviews Cancer
5:
626–639.
|
|
|
Chang KC,
Wang C and
Wang H
(2012)
Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells.
Bioessays
34:
301–310.
|
|
|
Chen CL,
Schroeder MC,
Kango-Singh M,
Tao C and
Halder G
(2012)
Tumor suppression by cell competition through regulation of the Hippo pathway.
Proceedings of the National Academy of Sciences of the USA
109:
484–489.
|
|
|
Cheng LY,
Bailey AP,
Leevers SJ et al.
(2011)
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.
Cell
146:
435–447.
|
|
|
Chi C,
Zhu H,
Han M et al.
(2010)
Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.
Journal of Biological Chemistry
285:
21817–21823.
|
|
|
Christiansen AE,
Ding T and
Bergmann A
(2012a)
Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.
Mechanisms of Development
129:
98–108.
|
|
|
Christiansen AE,
Ding T,
Fan Y et al.
(2012b)
Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila.
Cell Death and Differentiation
20(2):
302–311.
|
|
|
Classen AK,
Bunker BD,
Harvey KF,
Vaccari T and
Bilder D
(2009)
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling.
Nature Genetics
41:
1150–1155.
|
|
|
Cordero JB,
Macagno JP,
Stefanatos RK et al.
(2010)
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.
Developmental Cell
18:
999–1011.
|
|
|
Dar AC,
Das TK,
Shokat KM and
Cagan RL
(2012)
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
Nature
486:
80–84.
|
|
|
Das TK,
Sangodkar J,
Negre N,
Narla G and
Cagan RL
(2012)
Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors.
Oncogene [Epub ahead of print].
|
|
|
Doggett K,
Grusche FA,
Richardson HE and
Brumby AM
(2011)
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.
BMC Developmental Biology
11:
57.
|
|
|
Edwards A,
Gladstone M,
Yoon P et al.
(2011)
Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells.
Disease Models and Mechanisms
4:
496–503.
|
|
|
Elsum I,
Yates L,
Humbert PO and
Richardson HE
(2012)
The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.
Essays in Biochemistry
53:
141–168.
|
|
|
Fan Y and
Bergmann A
(2008)
Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!.
Trends in Cell Biology
18:
467–473.
|
|
|
Feng S,
Huang J and
Wang J
(2011)
Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation.
EMBO Reports
12:
157–163.
|
|
|
Ferres-Marco D,
Gutierrez-Garcia I,
Vallejo DM et al.
(2006)
Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.
Nature
439:
430–436.
|
|
|
Froldi F,
Ziosi M,
Garoia F et al.
(2010)
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy.
BMC Biology
8:
33.
|
|
|
Gladstone M,
Frederick B,
Zheng D et al.
(2012)
A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer.
Disease Models and Mechanisms
5:
342–350.
|
|
|
Graves HK,
Woodfield SE,
Yang CC,
Halder G and
Bergmann A
(2012)
Notch signaling activates Yorkie non-cell autonomously in Drosophila.
PLoS ONE
7:
e37615.
|
|
|
Grusche FA,
Degoutin JL,
Richardson HE and
Harvey KF
(2011)
The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.
Developmental Biology
350:
255–266.
|
|
|
Grusche FA,
Richardson HE and
Harvey KF
(2010)
Upstream regulation of the hippo size control pathway.
Current Biology
20:
R574–R582.
|
|
|
Grzeschik NA,
Parsons LM,
Allott ML,
Harvey KF and
Richardson HE
(2010a)
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.
Current Biology
20:
573–581.
|
|
|
Grzeschik NA,
Parsons LM and
Richardson HE
(2010b)
Lgl, the SWH pathway and tumorigenesis: it's a matter of context & competition!.
Cell Cycle
9:
3202–3212.
|
|
|
Hanahan D and
Weinberg RA
(2011)
Hallmarks of cancer: the next generation.
Cell
144:
646–674.
|
|
|
Herranz H,
Hong X,
Hung NT,
Voorhoeve PM and
Cohen SM
(2012)
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model.
Genes and Development
26:
1602–1611.
|
|
|
Herranz H,
Perez L,
Martin FA and
Milan M
(2008)
A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing.
EMBO Journal
27:
1633–1645.
|
|
|
Hogan C
(2012)
Impact of interactions between normal and transformed epithelial cells and the relevance to cancer.
Cellular and Molecular Life Sciences
69:
203–213.
|
|
|
Huse JT and
Holland EC
(2010)
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.
Nature Reviews Cancer
10:
319–331.
|
|
|
Igaki T,
Pastor-Pareja JC,
Aonuma H,
Miura M and
Xu T
(2009)
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila.
Developmental Cell
16:
458–465.
|
|
|
Janic A,
Mendizabal L,
Llamazares S,
Rossell D and
Gonzalez C
(2010)
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.
Science
330:
1824–1827.
|
|
|
Jiang H and
Edgar BA
(2012)
Intestinal stem cell function in Drosophila and mice.
Current Opinion in Genetics and Development
22:
354–360.
|
|
|
Jiang Y,
Scott KL,
Kwak SJ,
Chen R and
Mardon G
(2011)
Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.
Oncogene
30:
3248–3260.
|
|
|
Kagey JD,
Brown JA and
Moberg KH
(2012)
Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched.
Mechanisms of Development
129:
339–349.
|
|
|
Karpowicz P,
Perez J and
Perrimon N
(2010)
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration.
Development
137:
4135–4145.
|
|
|
Leong GR,
Goulding KR,
Amin N,
Richardson HE and
Brumby AM
(2009)
scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.
BMC Biology
7:
62.
|
|
|
Lolo FN,
Casas-Tinto S and
Moreno E
(2012)
Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes.
Cell Reports
2:
526–539.
|
|
|
Martinez AM,
Schuettengruber B,
Sakr S et al.
(2009)
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.
Nature Genetics
41:
1076–1082.
|
|
|
Menendez J,
Perez-Garijo A,
Calleja M and
Morata G
(2010)
A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway.
Proceedings of the National Academy of Sciences of the USA
107:
14651–14656.
|
|
|
Menut L,
Vaccari T,
Dionne H et al.
(2007)
A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation.
Genetics
177:
1667–1677.
|
|
|
Miller MR,
Robinson KJ,
Cleary MD and
Doe CQ
(2009)
TU-tagging: cell type-specific RNA isolation from intact complex tissues.
Nature Methods
6:
439–441.
|
|
|
Mummery-Widmer JL,
Yamazaki M,
Stoeger T et al.
(2009)
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.
Nature
458:
987–992.
|
|
|
Neto-Silva RM,
de Beco S and
Johnston LA
(2010)
Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap.
Developmental Cell
19:
507–520.
|
|
|
Norman M,
Wisniewska KA,
Lawrenson K et al.
(2012)
Loss of Scribble causes cell competition in mammalian cells.
Journal of Cell Science
125:
59–66.
|
|
|
O'Brien LE,
Soliman SS,
Li X and
Bilder D
(2011)
Altered modes of stem cell division drive adaptive intestinal growth.
Cell
147:
603–614.
|
|
|
Oh H and
Irvine KD
(2011)
Cooperative regulation of growth by Yorkie and Mad through bantam.
Developmental Cell
20:
109–122.
|
|
|
Ohsawa S,
Sato Y,
Enomoto M et al.
(2012)
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila.
Nature
490:
547–551.
|
|
|
Ohsawa S,
Sugimura K,
Takino K et al.
(2011)
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila.
Developmental Cell
20:
315–328.
|
|
|
Osman D,
Gobert V,
Ponthan F et al.
(2009)
A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO.
Proceedings of the National Academy of Sciences of the USA
106:
12043–12048.
|
|
|
Pallavi SK,
Ho DM,
Hicks C,
Miele L and
Artavanis-Tsakonas S
(2012)
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.
EMBO Journal
31:
2895–2907.
|
|
|
Palomero T,
Sulis ML,
Cortina M et al.
(2007)
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Nature Medicine
13:
1203–1210.
|
|
|
Pearson HB,
Perez-Mancera PA,
Dow LE et al.
(2011)
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.
Journal of Clinical Investigation
121:
4257–4267.
|
|
|
Petrova E,
Lopez-Gay JM,
Rhiner C and
Moreno E
(2012)
Flower-deficient mice have reduced susceptibility to skin papilloma formation.
Disease Models and Mechanisms
5:
553–561.
|
|
|
Petrova E,
Soldini D and
Moreno E
(2011)
The expression of SPARC in human tumors is consistent with its role during cell competition.
Communicative and Integrative Biology
4:
171–174.
|
|
|
Portela M,
Casas-Tinto S,
Rhiner C et al.
(2010)
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition.
Developmental Cell
19:
562–573.
|
|
|
Read RD,
CaveneeWK,
Furnari FB and
Thomas JB
(2009)
A Drosophila model for EGFR-Ras and PI3K-dependent human glioma.
PLoS Genetics
5:
e1000374.
|
|
|
Read RD,
Goodfellow PJ,
Mardis ER et al.
(2005)
A Drosophila model of multiple endocrine neoplasia type 2.
Genetics
171:
1057–1081.
|
|
|
Reddy BV,
Rauskolb C and
Irvine KD
(2010)
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia.
Development
137:
2397–2408.
|
|
|
Rhiner C,
Lopez-Gay JM,
Soldini D et al.
(2010)
Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.
Developmental Cell
18:
985–998.
|
|
|
Richardson HE
(2011)
Actin up for Hippo.
EMBO Journal
30:
2307–2309.
|
|
|
Robinson BS and
Moberg KH
(2011)
Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway.
Cell Cycle
10:
4110–4118.
|
|
|
Rodrigues AB,
Zoranovic T,
Ayala-Camargo A et al.
(2012)
Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis.
Development
139:
4051–4061.
|
|
|
Rossi F and
Gonzalez C
(2012)
Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.
EMBO Reports
13:
157–162.
|
|
|
Schroeder MC,
Chen CL,
Gajewski K and
Halder G
(2012)
A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells.
Oncogene [Epub ahead of print].
|
|
|
Sinenko SA,
Hung T,
Moroz T et al.
(2010)
Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model.
Blood
116:
4612–4620.
|
|
|
Staley BK and
Irvine KD
(2010)
Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation.
Current Biology
20:
1580–1587.
|
|
|
Stefanatos RK and
Vidal M
(2011)
Tumor invasion and metastasis in Drosophila: a bold past, a bright future.
Journal of Genetics and Genomics
38:
431–438.
|
|
|
Sun G and
Irvine KD
(2011)
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.
Developmental Biology
350:
139–151.
|
|
|
Uhlirova M,
Jasper H and
Bohmann D
(2005)
Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.
Proceedings of the National Academy of Sciences of the USA
102:
13123–13128.
|
|
|
Vaccari T and
Bilder D
(2009)
At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression.
Molecular Oncology
3:
354–365.
|
|
|
Vallejo DM,
Caparros E and
Dominguez M
(2011)
Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells.
EMBO Journal
30:
756–769.
|
|
|
VanZomeren-Dohm A,
Sarro J,
Flannery E and
Duman-Scheel M
(2011)
The Drosophila netrin receptor frazzled/DCC functions as an invasive tumor suppressor.
BMC Developmental Biology
11:
41.
|
|
|
Vidal M,
Salavaggione L,
Ylagan L et al.
(2010)
A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas.
American Journal of Pathology
176:
3007–3014.
|
|
|
Vidal M,
Wells S,
Ryan A and
Cagan R
(2005)
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.
Cancer Research
65:
3538–3541.
|
|
|
Vincent JP,
Kolahgar G,
Gagliardi M and
Piddini E
(2011)
Steep differences in wingless signaling trigger Myc-independent competitive cell interactions.
Developmental Cell
21:
366–374.
|
|
|
Wagner EF and
Nebreda AR
(2009)
Signal integration by JNK and p38 MAPK pathways in cancer development.
Nature Reviews Cancer
9:
537–549.
|
|
|
Warner SJ,
Yashiro H and
Longmore GD
(2010)
The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.
Current Biology
20:
677–686.
|
|
|
Willecke M,
Toggweiler J and
Basler K
(2011)
Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.
Oncogene
30:
4067–4074.
|
|
|
Willoughby LF,
Schlosser T,
Manning SA et al.
(2012)
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.
Disease Models and Mechanisms [Epub ahead of print].
|
|
|
Witte HT,
Jeibmann A,
Klambt C and
Paulus W
(2009)
Modeling glioma growth and invasion in Drosophila melanogaster.
Neoplasia
11:
882–888.
|
|
|
Wu M,
Pastor-Pareja JC and
Xu T
(2010)
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion.
Nature
463:
545–548.
|
|
|
Xiao Q,
Komori H and
Lee CY
(2012)
klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division.
Development
139:
2670–2680.
|
|
|
Zecca M and
Struhl G
(2010)
A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth.
PLoS Biology
8:
e1000386.
|
|
|
Zhai Z,
Ha N,
Papagiannouli F et al.
(2012)
Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila.
PLoS Genetics
8:
e1002582.
|
|
|
Zhang C,
Liu B,
Li G and
Zhou L
(2011)
Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila.
Journal of Genetics and Genomics
38:
453–460.
|
|
|
Zhang X,
Richardson HE and
Harvey KF
(2009)
Making brundlefly, one gene at a time.
Cell Research
19:
5–7.
|
|
|
Ziosi M,
Baena-Lopez LA,
Grifoni D et al.
(2010)
dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.
PLoS Genetics
6(9):
e1000386. doi:10.1371/journal.pgen.1001140
|
|
|
Ziv O,
Suissa Y,
Neuman H et al.
(2009)
The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling.
Development
136:
1137–1145.
|
| Further Reading |
|
|
Baena-Lopez LA,
Nojima H and
Vincent JP
(2012)
Integration of morphogen signalling within the growth regulatory network.
Current Opinion in Cell Biology
24(2):
166–172.
|
|
|
Boggiano JC and
Fehon RG
(2012)
Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signalling.
Developmental Cell
22(4):
695–702.
|
|
|
Das T and
Cagan R
(2010)
Drosophila as a novel therapeutic discovery tool for thyroid cancer.
Thyroid
20(7):
689–695.
|
|
|
Genevet A and
Tapon N
(2011)
The Hippo pathway and apico-basal cell polarity.
Biochemical Journal
436(2):
213–224.
|
|
|
Gladstone M and
Su TT
(2011)
Chemical genetics and drug screening in Drosophila cancer models.
Journal of Genetics and Genomics
38(10):
497–504.
|
|
|
Kasai Y and
Cagan R
(2010)
Drosophila as a tool for personalized medicine: a primer.
Per Med
7(6):
621–632.
|
|
|
Lesage B,
Gutierrez I,
Martí E and
Gonzalez C
(2010)
Neural stem cells: the need for a proper orientation.
Current Opinion in Genetics and Development
20(4):
438–442.
|
|
|
Miles WO,
Dyson NJ and
Walker JA
(2011)
Modeling tumor invasion and metastasis in Drosophila.
Disease Models and Mechanisms
4(6):
753–761.
|
|
|
Polesello C,
Roch F,
Gobert V,
Haenlin M and
Waltzer L
(2011)
Modelling cancers in Drosophila.
Progress in Molecular Biology and Translational Science
100:
51–82.
|
|
|
Read RD
(2011)
Drosophila melanogaster as a model system for human brain cancers.
Glia
59(9):
1364–1376.
|
|
|
Rudrapatna VA,
Cagan RL and
Das TK
(2012)
Drosophila cancer models.
Developmental Dynamics
241(1):
107–118.
|
|
|
Tamori Y and
Deng WM
(2011)
Cell competition and its implications for development and cancer.
Journal of Genetics and Genomics
38(10):
483–495.
|
|
|
Worley MI,
Setiawan L and
Hariharan IK
(2012)
Regeneration and transdetermination in Drosophila imaginal discs.
Annual Review of Genetics
46:
289–310.
|
