Mitochondria as a Key Determinant of Aging

Abstract

For a long time, mitochondria have been considered as primary targets of the aging process, notably through accumulation of oxidative damage and mitochondrial deoxyribonucleic acid (DNA) mutations that lead to gradual decline of mitochondrial function. Recent investigations in various model organisms have revealed conserved molecular pathways that can impact longevity. Intriguingly, some of these longevity pathways involve proteins with key functions in the mitochondria. Furthermore, a growing number of studies indicate that signals emanated from mitochondria can directly impact the longevity of the whole organism. Thus, the mitochondrion organelle likely plays an active and causal role in longevity determination. This renders mitochondria a key determinant in the complex network of physiological signals that modulates longevity.

Keywords: aging; signal transduction; mitochondria; ROS; dietary restriction

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Walter, Ludivine, and Lee, Siu Sylvia(Mar 2009) Mitochondria as a Key Determinant of Aging. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0020881]