| References |
|
|
Bishop NA and
Guarente L
(2007)
Two neurons mediate diet-restriction-induced longevity in C. elegans.
Nature
447:
545549.
|
|
|
Dillin A,
Hsu AL,
Arantes-Oliveira N et al.
(2002)
Rates of behavior and aging specified by mitochondrial function during development.
Science
298:
23982401.
|
|
|
Felkai S,
Ewbank JJ,
Lemieux J et al.
(1999)
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.
Embo Journal
18:
17831792.
|
|
|
Fridell YW,
Sanchez-Blanco A,
Silvia BA and
Helfand SL
(2005)
Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.
Cell Metabolism
1:
145152.
|
|
|
Harman D
(1956)
Aging: a theory based on free radical and radiation chemistry.
Journal of Gerontology
11:
298300.
|
|
|
Lee SS,
Lee RY,
Fraser AG et al.
(2003)
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
Nature Genetics
33:
4048.
|
|
|
Lin SJ,
Kaeberlein M,
Andalis AA et al.
(2002)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
Nature
418:
344348.
|
|
|
Liu X,
Jiang N,
Hughes B et al.
(2005)
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
Genes and Development
19:
24242434.
|
|
|
Migliaccio E,
Giorgio M,
Mele S et al.
(1999)
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Nature
402:
309313.
|
|
|
Miwa S,
Riyahi K,
Partridge L and
Brand MD
(2004)
Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila.
Annals of the New York Academy of Sciences
1019:
388391.
|
|
|
Nisoli E,
Tonello C,
Cardile A et al.
(2005)
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.
Science
310:
314317.
|
|
|
Panowski SH,
Wolff S,
Aguilaniu H,
Durieux J and
Dillin A
(2007)
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Nature
447:
550555.
|
|
|
Scheckhuber CQ,
Erjavec N,
Tinazli A et al.
(2007)
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models.
Nature Cell Biology
9:
99105.
|
|
|
Trifunovic A,
Wredenberg A,
Falkenberg M et al.
(2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Nature
429:
417423.
|
|
|
Tyynismaa H,
Mjosund KP,
Wanrooij S et al.
(2005)
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Proceedings of the National Academy of Sciences of the USA
102:
1768717692.
|
|
|
Vermulst M,
Bielas JH,
Kujoth GC et al.
(2007)
Mitochondrial point mutations do not limit the natural lifespan of mice.
Nature Genetics
39:
540543.
|
|
|
Zahn JM,
Poosala S,
Owen AB et al.
(2007)
AGEMAP: a gene expression database for aging in mice.
PLoS Genetics
3:
e201.
|
| Further Reading |
| On Mitochondria and Bioenergetics |
|
|
book
Nicholls DG and
Ferguson SJ
(2002)
Bioenergetics 3.
New York: Academic Press.
ISBN 0-12-518121-3.
|
| On the Section Mitochondrial ROS and Aging |
|
|
Muller FL,
Lustgarten MS,
Jang Y,
Richardson A and
Van Remmen H
(2007)
Trends in oxidative aging theories.
Free Radical Biology and Medicine
43:
477503.
|
|
|
Finkel T
(2001)
Reactive oxygen species and signal transduction.
IUBMB Life
52:
36.
|
| On the Section Mitochondrial DNA Mutations and Aging |
|
|
Krishnan KJ,
Greaves LC,
Reeve AK and
Turnbull DM
(2007)
Mitochondrial DNA mutations and aging.
Annals of the New York Academy of Sciences
1100:
227240.
|
| On the Section Mitochondria in Signal Transduction that Affects Lifespan upon Dietary Restriction |
|
|
Bishop NA and
Guarente L
(2007)
Genetic links between diet and lifespan: shared mechanisms from yeast to humans.
Nature Reviews Genetics
8:
835844.
|
|
|
Kelly DP and
Scarpulla RC
(2004)
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function.
Genes and Development
18:
357368.
|
|
|
Lin SJ and
Guarente L
(2003)
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
Current Opinion in Cell Biology
15(2):
241246.
|
|
|
Speakman JR,
Talbot DA,
Selman C et al.
(2004)
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer.
Aging Cell
3:
8795.
|
| On the Section Inhibition of Mitochondrial Function in Signal Transduction that Affects Aging |
|
|
Liu Z and
Butow RA
(2006)
Mitochondrial retrograde signaling.
Annual Review of Genetics
40:
159185.
|