Comparing the Human and Medaka Genomes

Abstract

Medaka (Oryzias latipes) is a small teleost fish for which well‐established resources for genetic and genomic studies are available, hence, medaka has become an excellent laboratory model animal for life sciences. Comparing the human and medaka genomes provided novel information on the sets of genes, repetitive elements, gene regulatory elements and the evolutionary conserved elements at the nucleotide sequence level. The genomic information implied chromosomal evolution in the vertebrate lineage and the use of medaka for medical science.

Keywords: human; medaka; genome; genes; repetitive elements; evolution

Figure 1.

Comparison of conserved gene clusters (CGCs) and orthologues between medaka chromosome LG22 and the human chromosomes. (a) Distribution of the 122 CGCs between medaka LG22 and 15 different human chromosomes. The CGC is classified into five groups by the number of included genes which are shown in different colours. (b) Distribution of 338 orthologues between medaka LG22 and 15 different human chromosomes. Triangles in each row represent the position and direction of genes in each species.

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Further Reading

Chen WJ, Orti G and Meyer A (2004) Novel evolutionary relationship among four fish model systems. Trends in Genetics 20: 424–431.

Naruse K, Hori H, Shimizu N, Kohara Y and Takeda H (2004) Medaka genomics: a bridge between mutant phenotype and gene function. Mechanisms of Development 121: 619–628.

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Web links

Ensembl http://www.ensembl.org/index.html

Keio Medaka Ensembl http://keioensembl.dmb.med.keio.ac.jp/

NCBI Map Viewer: Homo sapiens Build 36.2 http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?taxid=9606

UT Genome Browser (Medaka) http://medaka.utgenome.org/

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How to Cite close
Sasaki, Takashi, and Shimizu, Nobuyoshi(Jul 2008) Comparing the Human and Medaka Genomes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0021010]