The frontal lobes are the largest and likely most complex structure in the brain. Among other functions, it allows the expression of personality and language, the planning and sequencing of desired movements or actions as well as inhibition of unwanted or undesirable ones. Given the regional distribution of function, lesions or dysfunction in the frontal lobes may lead to such range of personal and social disruptions as aphasia, perseveration, disinhibition, personality changes and acquired sociopathy. Besides trauma, tumours, infections and toxins, abnormal disorders of tau and ubiquitin proteins may lead to neurodegenerative diseases that predominantly affect the frontal lobes. These so‐called frontotemporal dementias or frontotemporal lobar degenerations have become the most active and exciting field of research in the frontal lobes.
These are the most salient functions and dysfunctions of the frontal lobes discussed here:
Keywords: frontal lobes; personality changes; executive dysfunction; Broca's aphasia; frontemporal dementia