| References |
|
|
Berube C,
Boucher LM,
Ma W et al.
(2005)
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Proceedings of the National Academy of Sciences of the USA
102:
1431414320.
|
|
|
Burckstummer T,
Baumann C,
Bluml S et al.
(2009)
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Nature Immunology
10:
266272.
|
|
|
Chinnaiyan AM,
O'Rourke K,
Tewari M and
Dixit VM
(1995)
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
Cell
81:
505512.
|
|
|
Duan H and
Dixit VM
(1997)
RAIDD is a new death adaptor molecule.
Nature
385:
8689.
|
|
|
Eberstadt M,
Huang B,
Chen Z et al.
(1998)
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature
392:
941945.
|
|
|
Fernandes-Alnemri T,
Yu JW,
Datta P,
Wu J and
Alnemri ES
(2009)
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Nature
458:
509513.
|
|
|
Franchi L,
Eigenbrod T,
Munoz-Planillo R and
Nunez G
(2009)
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.
Nature Immunology
10:
241247.
|
|
|
Hiller S,
Kohl A,
Fiorito F et al.
(2003)
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Structure
11:
11991205.
|
|
|
Hornung V,
Ablasser A,
Charrel-Dennis M et al.
(2009)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Nature
458:
514518.
|
|
|
Huang B,
Eberstadt M,
Olejniczak ET,
Meadows RP and
Fesik SW
(1996)
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
Nature
384:
638641.
|
|
|
Kischkel FC,
Hellbardt S,
Behrmann I et al.
(1995)
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
EMBO Journal
14:
55795588.
|
|
|
Lassus P,
Opitz-Araya X and
Lazebnik Y
(2002)
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization.
Science
297:
13521354.
|
|
|
Li FY,
Jeffrey PD,
Yu JW and
Shi Y
(2006)
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling.
Journal of Biological Chemistry
281:
29602968.
|
|
|
Li P,
Nijhawan D,
Budihardjo I et al.
(1997)
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Cell
91:
479489.
|
|
|
Liepinsh E,
Barbals R,
Dahl E et al.
(2003)
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition.
Journal of Molecular Biology
332:
11551163.
|
|
|
Lin Y,
Ma W and
Benchimol S
(2000)
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.
Nature Genetics
26:
122127.
|
|
|
McEntyre JR and
Gibson TJ
(2004)
Patterns and clusters within the PSM column in TiBS, 19922004.
Trends in Biochemical Science
29:
627633.
|
|
|
Natarajan A,
Ghose R and
Hill JM
(2006)
Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling.
Journal of Biological Chemistry
281:
3186331875.
|
|
|
Park HH and
Wu H
(2006)
Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly.
Journal of Molecular Biology
357:
358364.
|
|
|
Park HH,
Lo YC,
Lin SC et al.
(2007a)
The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Annual Review of Immunology
25:
561586.
|
|
|
Park HH,
Logette E,
Rauser S et al.
(2007b)
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.
Cell
128:
533546.
|
|
|
Poppema S,
Maggio E and
van den Berg A
(2004)
Development of lymphoma in autoimmune lymphoproliferative syndrome (ALPS) and its relationship to Fas gene mutations.
Leukemia & Lymphoma
45:
423431.
|
|
|
Qin H,
Srinivasula SM,
Wu G et al.
(1999)
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature
399:
549557.
|
|
|
Rathmell JC and
Thompson CB
(2002)
Pathways of apoptosis in lymphocyte development, homeostasis, and disease.
Cell
109(suppl.):
S97S107.
|
|
|
Reed JC,
Doctor KS and
Godzik A
(2004)
The domains of apoptosis: a genomics perspective.
Science's STKE
2004:
re9.
|
|
|
Riedl SJ and
Shi Y
(2004)
Molecular mechanisms of caspase regulation during apoptosis.
Nature Reviews. Molecular Cell Biology
5:
897907.
|
|
|
Riedl SJ,
Li W,
Chao Y,
Schwarzenbacher R and
Shi Y
(2005)
Structure of the apoptotic protease-activating factor 1 bound to ADP.
Nature
434:
926933.
|
|
|
Rieux-Laucat F,
Fischer A and
Deist FL
(2003a)
Cell-death signaling and human disease.
Current Opinion in Immunology
15:
325331.
|
|
|
Rieux-Laucat F,
Le Deist F and
Fischer A
(2003b)
Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways.
Cell Death and Differentiation
10:
124133.
|
|
|
Roberts TL,
Idris A,
Dunn JA et al.
(2009)
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.
Science
323:
10571060.
|
|
|
Salvesen GS and
Dixit VM
(1999)
Caspase activation: the induced-proximity model.
Proceedings of the National Academy of Sciences of the USA
96:
1096410967.
|
|
|
Scott FL,
Stec B,
Pop C et al.
(2009)
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature
457:
10191022.
|
|
|
Shisler JL and
Moss B
(2001)
Molluscum contagiosum virus inhibitors of apoptosis: the MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein.
Virology
282:
1425.
|
|
|
Tartaglia LA,
Ayres TM,
Wong GH and
Goeddel DV
(1993)
A novel domain within the 55 kd TNF receptor signals cell death.
Cell
74:
845853.
|
|
|
Thome M and
Tschopp J
(2001)
Regulation of lymphocyte proliferation and death by FLIP.
Nature Reviews. Immunology
1:
5058.
|
|
|
Tinel A and
Tschopp J
(2004)
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.
Science
304:
843846.
|
|
|
Wajant H
(2002)
The Fas signaling pathway: more than a paradigm.
Science
296:
16351636.
|
|
|
Wang L,
Miura M,
Bergeron L,
Zhu H and
Yuan J
(1994)
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.
Cell
78:
739750.
|
|
|
Xiao T,
Towb P,
Wasserman SA and
Sprang SR
(1999)
Three-dimensional structure of a complex between the death domains of Pelle and Tube.
Cell
99:
545555.
|
|
|
Yang JK,
Wang L,
Zheng L et al.
(2005)
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Molecular Cell
20:
939949.
|
| Further Reading |
|
|
Damiano JS and
Reed JC
(2004)
CARD proteins as therapeutic targets in cancer.
Current Drug Targets
5:
367374.
|
|
|
Hong GS and
Jung YK
(2002)
Caspase recruitment domain (CARD) as a bi-functional switch of caspase regulation and NF-kappaB signals.
Journal of Biochemistry and Molecular Biology
35:
1923.
|
|
|
Valmiki MG and
Ramos JW
(2009)
Death effector domain-containing proteins.
Cell Mol Life Sci
66:
814830.
|
|
|
Yu JW and
Shi Y
(2008)
FLIP and the death effector domain family.
Oncogene
27:
62166227.
|