Evolution of Nuclear Receptor Pseudogenes

Abstract

Nuclear receptors (NRs) are transcription factors with deoxyribonucleic acid (DNA)‐binding and ligand‐receptor domains. When activated by ligands, they bind to the regulatory regions of target genes to regulate transcription. NR genes comprise relatively large gene families derived from a single metazoan parent gene through evolutionary duplication and divergence, which often produces duplication (unprocessed) pseudogenes. However, no NR duplication pseudogenes have been found in genomes examined to date. A small number of NR retropseudogenes (processed pseudogenes), and a single unitary pseudogene have been identified in the annotated human, chimpanzee, mouse and rat genomes. The unitary pseudogene (ψFXRβ) is exclusive to catarrhines and arose via mutational inactivation of the FXRβ gene, which is an active gene in murids. The human‐specific ψERRα+ pseudogene arose through duplication of a DNA segment containing the ψERRα–retropseudogene and is an example of a duplication retropseudogene. The murid ψRev‐erbβ and ψLRH1 pseudogenes are examples semiprocessed retropseudogenes.

Key concepts

  • There are relatively few nuclear receptor pseudogenes in vertebrate genomes.

  • Identified nuclear receptor genes consist of retropseudogenes and a single unitary pseudogene.

Keywords: nuclear receptor genes; pseudogenes; unitary pseudogenes; retropseudogenes

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Further Reading

Balakirev ES and Ayala FJ (2003) Pseudogenes: are they “junk” or functional DNA? Annual Review of Genetics 37: 123–151.

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Zhou Q and Wang W (2008) On the origin and evolution of new genes: a genomic and experimental perspective. Journal of Genetics and Genomics 35: 639–648.

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How to Cite close
Fairbanks, Daniel J(Dec 2009) Evolution of Nuclear Receptor Pseudogenes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0021760]