| References |
|
|
Aydin S,
Ozkan Y,
Caylak E and
Aydin S
(2006)
Ghrelin and its biochemical functions: Review.
Journal of Medical Sciences
26(3):
272–283.
|
|
|
Baldanzi G,
Filigheddu N,
Cutrupi S et al.
(2002)
Ghrelin and des‐acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3‐kinase/AKT.
Journal of Cell Biology
159(6):
1029–1037.
|
|
|
Barazzoni R,
Bosutti A,
Stebel M et al.
(2004)
Ghrelin regulates mitochondrial‐lipid metabolism gene expression and tissue fat distribution favoring triglyceride deposition in liver but not skeletal muscle.
American Journal of Physiology – Endocrinology and Metabolism
288(1):
E228–E235.
|
|
|
Barreiro ML,
Gaytan F,
Castellano JM et al.
(2004)
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger RNA expression in rat testis.
Endocrinology
145(11):
4825–4834.
|
|
|
Bizzarri C,
Rigamonti AE,
Luce A et al.
(2010)
Children with Prader‐Willi syndrome exhibit more evident meal‐induced responses in plasma ghrelin and peptide YY levels than obese and lean children.
European Journal of Endocrinology
162(3):
499–505.
|
|
|
Broglio F,
Gianotti L,
Destefanis S et al.
(2004)
The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state.
Clinical Endocrinology (Oxford)
60(5):
592–599.
|
|
|
Brzozowski T,
Konturek PC,
Konturek SJ et al.
(2004)
Exogenous and endogenous ghrelin in gastroprotection against stress induced gastric damage.
Regulatory Peptides
120(1–3):
39–51.
|
|
|
Cassoni P,
Ghe C,
Marrocco T et al.
(2004)
Expression of ghrelin and biological activity of specific receptors for ghrelin and des‐acyl ghrelin in human prostate neoplasms and related cell lines.
European Journal of Endocrinology
150(2):
173–184.
|
|
|
Cassoni P,
Papotti M,
Ghe C et al.
(2001)
Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines.
Journal of Clinical Endocrinology and Metabolism
86(4):
1738–1745.
|
|
|
Celi F,
Bini V,
Papi F et al.
(2005)
Circulating acylated and total ghrelin and galanin in children with insulin‐treated type 1 diabetes: relationship to insulin therapy, metabolic control and pubertal development.
Clinical Endocrinology (Oxford)
63(2):
139–145.
|
|
|
Chang L,
Ren Y,
Liu X et al.
(2004)
Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart.
Journal of Cardiovascular Pharmacology
43(2):
165–170.
|
|
|
Chen CY,
Chao Y,
Chang FY et al.
(2005)
Intracisternal des‐acyl ghrelin inhibits food intake and non‐nutrient gastric emptying in conscious rats.
International Journal of Molecular Medicine
16(4):
695–699.
|
|
|
Chen HY,
Trumbauer ME,
Chen AS et al.
(2004)
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti‐related protein.
Endocrinology
145(6):
2607–2612.
|
|
|
Deveci Y,
Deveci F,
Ilhan N et al.
(2010)
Serum ghrelin, IL‐6 and TNF‐α levels in patients with chronic obstructive pulmonary disease.
Tuberkuloz Toraks
58(2):
162–172.
|
|
|
Dixit VD,
Schaffer EM,
Pyle RS et al.
(2004)
Ghrelin inhibits leptin‐ and activation‐induced proinflammatory cytokine expression by human monocytes and T cells.
Journal of Clinical Investigation
114(1):
57–66.
|
|
|
Fernandez‐Fernandez R,
Tena‐Sempere M,
Navarro VM et al.
(2005)
Effects of ghrelin upon gonadotropin‐releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies.
Neuroendocrinology
82(5–6):
245–255.
|
|
|
Fuglsang J,
Skjaerbaek C,
Espelund U et al.
(2005)
Ghrelin and its relationship to growth hormones during normal pregnancy.
Clinical Endocrinology
62(5):
554–559.
|
|
|
Gauna C,
Meyler FM,
Janssen JA et al.
(2004)
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
Journal of Clinical Endocrinology and Metabolism
89(10):
5035–5042.
|
|
|
Gelling RW,
Overduin J,
Morrison CD et al.
(2004)
Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin‐induced feeding.
Endocrinology
145(10):
4575–4582.
|
|
|
Gonzalez‐Rey E,
Chorny A and
Delgado M
(2006)
Therapeutic action of ghrelin in a mouse model of colitis.
Gastroenterology
130(6):
1707–1720.
|
|
|
Goldstone AP,
Thomas EL,
Brynes AE et al.
(2004)
Elevated fasting plasma ghrelin in Prader–Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance.
Journal of Clinical Endocrinology and Metabolism
89(4):
1718–1726.
|
|
|
Haqq AM,
Grambow SC,
Muehlbauer M et al.
(2008)
Ghrelin concentrations in Prader–Willi syndrome (PWS) infants and children: changes during development.
Clinical Endocrinology (Oxford)
69(6):
911–920.
|
|
|
Hehir MP,
Glavey SV and
Morrison JJ
(2008)
Uterorelaxant effect of ghrelin on human myometrial contractility.
American Journal of Obstetrics and Gynecology
198(3):
323, e1‐5.
|
|
|
Jeffery PL,
Herington AC and
Chopin LK
(2002)
Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines.
Journal of Endocrinology
172(3):
R7–R11.
|
|
|
Kawamura K,
Sato N,
Fukuda J et al.
(2003)
Ghrelin inhibits the development of mouse preimplantation embryos in vitro.
Endocrinology
144(6):
2623–2633.
|
|
|
Kojima M
(2008)
The discovery of ghrelin – a personal memory.
Regulatory Peptides
145(1‐3):
2–6.
|
|
|
Kola B,
Hubina E,
Tucci SA et al.
(2005)
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP‐activated protein kinase.
Journal of Biological Chemistry
280(26):
25196–25201.
|
|
|
Komarowska H,
Wasko R,
Iwanik K et al.
(2006)
Ghrelin ovarian cell expression in patients with polycystic ovary syndrome: an immunohistochemical evaluation.
Hormone and Metabolic Research
38(12):
783–788.
|
|
|
Koo GC,
Huang C,
Camacho R et al.
(2001)
Immune enhancing effect of a growth hormone secretagogue.
Journal of Immunology
166(6):
4195–4201.
|
|
|
Liu G,
Fortin JP,
Beinborn M and
Kopin AS
(2007)
Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities.
Journal of Pharmacology and Experimental Therapeutics
322(3):
1036–1043.
|
|
|
Maccarinelli G,
Sibilia V,
Torsello A et al.
(2005)
Ghrelin regulates proliferation and differentiation of osteoblastic cells.
Journal of Endocrinology
184(1):
249–256.
|
|
|
Masuda Y,
Tanaka T,
Inomata N et al.
(2000)
Ghrelin stimulates gastric acid secretion and motility in rats.
Biochemical and Biophysical Research Communications
276(3):
905–908.
|
|
|
Misra M,
Miller KK,
Stewart V et al.
(2005)
Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents.
Journal of Clinical Endocrinology and Metabolism
90(9):
5082–5087.
|
|
|
Murata M,
Okimura Y,
Iida K et al.
(2002)
Ghrelin modulates the downstream molecules of insulin‐signaling in hepatoma cells.
Journal of Biological Chemistry
227(7):
5667–5674.
|
|
|
Nagaya N,
Kojima M,
Uematsu M et al.
(2001a)
Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.
American Journal of Physiology – Regulatory, Integrative and Comparative Physiology
280(5):
1483–1487.
|
|
|
Nagaya N,
Uematsu M,
Kojima M et al.
(2001b)
Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors.
Circulation
104(17):
2034–2038.
|
|
|
Pagotto U,
Gambineri A,
Pelusi C et al.
(2003)
Testosterone replacement therapy restores normal ghrelin in hypogonadal men.
The Journal of Clinical Endocrinology and Metabolism
88(8):
4139–4143.
|
|
|
Panidis D,
Asteriadis C,
Georgopoulos NA et al.
(2010)
Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome.
European Journal of Obstetrics and Gynecology and Reproductive Biology
149(2):
170–174.
|
|
|
Patel AD,
Stanley SA,
Murphy KG et al.
(2006)
Ghrelin stimulates insulin‐induced glucose uptake in adipocytes.
Regulatory Peptides
134(1):
17–22.
|
|
|
Poykko SM,
Kellokoski E,
Horkko S et al.
(2003)
Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes.
Diabetes
52(10):
2546–2553.
|
|
|
Rak A and
Gregoraszczuk EL
(2007)
Local feedback loop of ghrelin‐ GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis.
Growth Hormone and IGF Research
18(3):
221–227.
|
|
|
Santos M,
Bastos P,
Gonzaga S et al.
(2006)
Ghrelin expression in human and rat fetal lungs and the effect of ghrelin administration in nitrofen‐induced congenital diaphragmatic hernia.
Pediatric Research
59(4 pt 1):
531–537.
|
|
|
Schwartz MW,
Woods SC,
Porte D Jr,
Seeley RJ and
Baskin DG
(2000)
Brainstem integrative function in the central nervous system control of food intake.
Forum of Nutrition
63:
141–151.
|
|
|
Seim I,
Josh P,
Cunningham P,
Herington A and
Chopin L
(2011)
Ghrelin axis genes, peptides and receptors: recent findings and future challenges.
Molecular and Cellular Endocrinology
340(1):
3–9.
|
|
|
Shinde UA,
Desai KM,
Yu C and
Gopalakrishnan V
(2005)
Nitric oxide synthase inhibition exaggerates the hypotensive response to ghrelin: role of calcium‐activated potassium channels.
Journal of Hypertension
23(4):
779–784.
|
|
|
Sibilia V,
Pagani F,
Guidobono F et al.
(2002)
Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats.
Neuroendocrinology
75(2):
92–97.
|
|
|
Tack J,
Depoortere I,
Bisschops R et al.
(2006)
Influence of ghrelin on interdigestive gastrointestinal motility in humans.
Gut
55(3):
327–333.
|
|
|
Tanaka K,
Minoura H,
Isobe T et al.
(2003)
Ghrelin is involved in the decidualization of human endometrial stromal cells.
Journal of Clinical Endocrinology and Metabolism
88(5):
2335–2340.
|
|
|
Tena‐Sempere M
(2005)
Ghrelin: novel regulator of gonadal function.
Journal of Endocrinological Investigation
28(suppl. 5):
26–29.
|
|
|
Terashi M,
Asakawa A,
Harada T et al.
(2011)
Ghrelin reactive autoantibodies in restrictive anorexia nervosa.
Nutrition
27(4):
407–413.
|
|
|
Tesauro M,
Schinzari F,
Iantorno M et al.
(2005)
Ghrelin improves endothelial function in patients with metabolic syndrome.
Circulation
112(19):
2986–1992.
|
|
|
Tschop M,
Smiley DL and
Heiman ML
(2000)
Ghrelin induces adiposity in rodents.
Nature
407(6806):
908–913.
|
|
|
Tschop M,
Weyer C,
Tataranni PA et al.
(2001)
Circulating ghrelin levels are decreased in human obesity.
Diabetes
50(4):
707–709.
|
|
|
Tsubone T,
Masaki T,
Katsuragi I et al.
(2005)
Effects of pravastatin on obesity, diabetes, and adiponectin in diet‐induced obese mice.
American Journal of Physiology – Regulatory, Integrative and Comparative Physiology
289(6):
R1703–R1706.
|
|
|
Volante M,
Fulcheri E,
Allia E et al.
(2002)
Ghrelin expression in fetal, infant, and adult human lung.
Journal of Histochemistry and Cytochemistry
50(8):
1013–1021.
|
|
|
Wolf I,
Sadetzki S,
Kanety H et al.
(2006)
Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients.
Cancer
106(4):
966–973.
|
|
|
Yang J,
Brown MS,
Liang G,
Grishin NV and
Goldstein JL
(2008)
Identification of the acyltransferase that octanoylates ghrelin, an appetite‐stimulating peptide hormone.
Cell
132(3):
387–396.
|
|
|
Yoshimoto A,
Mori K,
Sugawara A et al.
(2002)
Plasma ghrelin and desacyl ghrelin concentrations in renal failure.
Journal of the American Society of Nephrology
13(11):
2748–2752.
|
|
|
Zhang JV,
Ren PG,
Avsian‐Kretchmer O et al.
(2005)
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
Science
310(5750):
996–999.
|
|
|
Zhao D,
Zhan Y,
Zeng H et al.
(2006)
Ghrelin stimulates interleukin‐8 gene expression through protein kinase C‐mediated NF‐kappaB pathway in human colonic epithelial cells.
Journal of Cellular Biochemistry
97(6):
1317–1327.
|
| Further Reading |
|
|
Aydin S
(2007)
Discovery of Ghrelin Hormone: Research and Clinical Applications.
Turkish Journal of Biochemistry
32(2):
272–283.
|
|
|
Itoh T,
Nagaya N,
Yoshikawa M et al.
(2004)
Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease.
American Journal of Respiratory and Critical Care Medicine
170(8):
879–882.
|
|
|
Toshinai K,
Yamaguchi H,
Sun Y et al.
(2006)
Des‐acyl ghrelin induced food intake by a mechanism independent of the growth hormone secretagogue receptor.
Endocrinology
147(5):
2306–2314.
|
|
|
Valassi E,
Scacchi M and
Cavagnini F
(2008)
Neuroendocrine control of food intake.
Nutrition, Metabolism and Cardiovascular Diseases
18(2):
158–168.
|
|
|
book
Williams G and
Frühbeck Gema (eds)
(2009)
Obesity: Science to Practice.
Oxford: John Wiley & Sons, Ltd.
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