Life Sciences in China

Abstract

Modern life sciences have been introduced into China from the West for more than 170 years; however, the fast progress was only seen in the past three decades. How China feeds its people and keeps them healthy remains a mystery for many Westerners. Chinese life scientists have done their best to increase the yields of rice and other crops, and develop vaccines and treatments to combat the major diseases in China. Thanks to the fast growing economy, the Chinese government input in research and development was significantly increased and led to the great leap forward of life sciences in the past 30 years. The stories behind the past and present life sciences in China are permeated with legends, and they are worthwhile knowing.

Key Concepts

  • Life sciences in China are mainly supported by the government.
  • The Chinese government looks at life sciences as the driving force for sustainable economic growth.
  • Feeding the huge population and keeping the people healthy are the main challenges faced by Chinese life scientists.
  • The leap forward of genomics and the significant increase of government input led to the fast progress of life sciences in China.
  • Stem cell research and neuroscience are the fastest growing fields in China.

Keywords: life sciences; China; publication; NSFC; CAS

Figure 1. Annual gross expenditure of R&D in China (2003–2012) (billion RMB).
Figure 2. Annual budget of NSFC (2003–2012) (billion RMB).
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References

Cao Y, He M, Gao Z, et al. (2014) Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome. Science 344 (6186): 913–917.

Chen H, Sun H, You F, et al. (2011) Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147 (2): 436–446.

Chen W, Han C, Xie B, et al. (2013) Induction of siglec‐G by RNA viruses inhibits the innate immune response by promoting RIG‐I degradation. Cell 152 (3): 467–478.

Deng T, Wang X, Fortelius M, et al. (2011) Out of Tibet: Pliocene Woolly Rhino suggests high‐plateau origin of ice age megaherbivores. Science 333 (6047): 1285–1288.

Gao H, Sun Y, Wu Y, et al. (2004) Identification of β‐Arrestin2 as a G protein‐coupled receptor‐stimulated regulator of NF‐κB pathways. Molecular Cell 14 (3): 303–317.

Guan CB, Xu HT, Jin M, Yuan XB and Poo MM (2007) Long‐range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit‐2. Cell 129 (2): 385–395.

Huang X, Kurata N, Wei X, et al. (2012a) A map of rice genome variation reveals the origin of cultivated rice. Nature 490 (7421): 497–501.

Huang J, Deng Q, Wang Q, et al. (2012b) Exome sequencing of hepatitis B virus‐associated hepatocellular carcinoma. Nature Genetics 44 (10): 1117–1121.

Jia J, Zhao S, Kong X, et al. (2013) Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature 496 (7443): 91–95.

Jiang H, Guo W, Liang X and Rao Y (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK‐3 beta and its upstream regulators. Cell 120 (1): 123–135.

Ke YH, Su B, Song X, et al. (2001) African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292 (5519): 1151–1153.

Li KS, Guan Y, Wang J, et al. (2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430 (6996): 209–213.

Li R, Fan W, Tian G, et al. (2010a) The sequence and de novo assembly of the giant panda genome. Nature 463 (7279): 311–317.

Li AA, Gong H, Zhang B, et al. (2010b) Micro‐optical sectioning tomography to obtain a high‐resolution atlas of the mouse brain. Science 330 (6009): 1404–1408.

Lin SY, Li TY, Liu Q, et al. (2012) GSK3‐TIP60‐ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336 (6080): 477–481.

Ling HQ, Zhao S, Liu D, et al. (2013) Draft genome of the wheat A‐genome progenitor Triticum urartu. Nature 496 (7443): 87–90.

Liu Z, Yan H, Wang K, et al. (2004) Crystal structure of spinach major light‐harvesting complex at 2.72 A resolution. Nature 428 (6980): 287–292.

Liu J, Xia H, Kim M, et al. (2011a) Beclin1 controls the Levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 (1): 223–234.

Liu Y, Jiang Y, Si Y, et al. (2011b) Molecular regulation of sexual preference revealed by genetic studies of 5‐HT in the brains of male mice. Nature 472 (7341): 95–99.

Lu YH, Wu K, Jiang Y, et al. (2010) Mirid bug outbreaks in multiple crops correlated with wide‐scale adoption of Bt cotton in China. Science 328 (5982): 1151–1154.

Lu JC, Unwin DM, Deeming DC, et al. (2011) An egg‐adult association, gender, and reproduction in Pterosaurs. Science 331 (6015): 321–324.

Lu Y, Wu K, Jiang Y, Guo Y and Desneux N (2012) Widespread adoption of Bt cotton and insecticide decrease promotes biocontrol services. Nature 487 (7407): 362–365.

Ren SX, Fu G, Jiang XG, et al. (2003) Unique physiological and pathogenic features of Leptospira interrogans revealed by whole‐genome sequencing. Nature 422 (6934): 888–893.

Shi Y, Feng Y, Kang J, et al. (2007) Critical regulation of CD4+ T cell survival and autoimmunity by beta‐arrestin 1. Nature Immunology 8 (8): 817–824.

Shu J, Wu C, Wu Y, et al. (2013) Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 153 (5): 963–975.

Shuai Y, Lu B, Hu Y, et al. (2010) Forgetting is regulated through Rac activity in drosophila. Cell 140 (4): 579–589.

Song H and Ming G (2014) Reprogram to pluripotency: a new logic and a chemical cocktail. National Science Review 1 (1): 6–7.

Song HD, Tu CC, Zhang GW, et al. (2005) Cross‐host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proceedings of the National Academy of Sciences of the United States of America 102 (7): 2430–2435.

Song AH, Wang D, Chen G, et al. (2009) A selective filter for cytoplasmic transport at the axon initial segment. Cell 136 (6): 1148–1160.

Sun F, Huo X, Zhai Y, et al. (2005) Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121 (7): 1043–1057.

Sun L, Wang H, Wang Z, et al. (2012) Mixed lineage kinase domain‐like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 (1–2): 213–227.

Wang ZY and Chen Z (2000) Differentiation and apoptosis induction therapy in acute promyelocytic leukaemia. Lancet Oncology 1: 101–106.

Wang P, Xue Y, Han Y, et al. (2014) The STAT3‐binding long noncoding RNA lnc‐DC controls human dendritic cell differentiation. Science 344 (6181): 310–313.

Wen B, Li H, Lu D, et al. (2004) Genetic evidence supports demic diffusion of Han culture. Nature 431 (7006): 302–305.

Wu QF, Yang L, Li S, et al. (2012) Fibroblast growth factor 13 is a microtubule‐stabilizing protein regulating neuronal polarization and migration. Cell 149 (7): 1549–1564.

Xu X, Zhou Z and Prum RO (2001) Branched integumental structures in Sinornithosaurus and the origin of feathers. Nature 410 (6825): 200–204.

Xu Y, Wang L, He J, et al. (2013) Prevalence and control of diabetes in Chinese adults. Jama‐Journal of the American Medical Association 310 (9): 948–958.

Xue G, Dong Q, Chen C, et al. (2010) Greater neural pattern similarity across repetitions Is associated with better memory. Science 330 (6000): 97–101.

Yan XJ, Xu J, Gu ZH, et al. (2011) Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genetics 43 (4): 309–315.

Yang W (2013) Research integrity in China. Science 342 (6162): 1019.

Yang W, Lu J, Weng J, et al. (2010) Prevalence of Diabetes among Men and Women in China. New England Journal of Medicine 362 (12): 1090–1101.

Yang JY, Zhao X, Cheng K, et al. (2012) A killer‐protector system regulates both hybrid sterility and segregation distortion in rice. Science 337 (6100): 1336–1340.

Yu J, Hu S, Wang J, et al. (2002) A draft sequence of the rice genome (Oryza sativa L. ssp indica). Science 296 (5565): 79–92.

Yu XJ, Liang MF, Zhang SY, et al. (2011) Fever with thrombocytopenia associated with a novel Bunyavirus in China. New England Journal of Medicine 364 (16): 1523–1532.

Yu Y, Chen Y, Kim B, et al. (2013) Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell 152 (1–2): 248–261.

Zhang L, Liu X, Li Y, et al. (2012a) Emergency medical rescue efforts after a major earthquake: lessons from the 2008 Wenchuan earthquake. Lancet 379 (9818): 853–861.

Zhang L, Wang F, Wang L, et al. (2012b) Prevalence of chronic kidney disease in China: a cross‐sectional survey. Lancet 379 (9818): 815–822.

Zhao XY, Li W, Lv Z, et al. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461 (7260): 86–90.

Zhou Y, Zheng HJ, Chen YY, et al. (2009) The Schistosoma japonicum genome reveals features of host‐parasite interplay. Nature 460 (7253): 345–351.

Zhou CM, Zhang TQ, Wang X, et al. (2013) Molecular basis of age‐dependent vernalization in Cardamine flexuosa. Science 340 (6136): 1097–1100.

Further reading

Adams J, King C and Ma N (2009). Global Research Report: China.

Cao X (2008) Immunology in China: the past, present and future. Nature Immunology 9 (4): 339–342.

Chen Z, Wang HG, Wen ZJ and Wang Y (2007) Life sciences and biotechnology in China. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 362 (1482): 947–957.

Chong K and Xu Z (2014) Investment in plant research and development bears fruit in China. Plant Cell Reports 33 (4): 541–550.

Huang J, Rozelle S, Pray C and Wang Q (2002) Plant biotechnology in China. Science 295 (5555): 674–676.

Gong Z, Liu J, Guo C, et al. (2010) Two pairs of neurons in the central brain control Drosophila innate light preference. Science 330 (6003): 499–502.

Guan J‐S, Xu ZZ, Gao H, et al. (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ‐opioid receptors and opioid analgesia. Cell 122 (4): 619–631.

Guo J and Guo A (2005) Crossmodal interactions between olfactory and visual learning in Drosophila. Science 309 (5732): 307–310.

International HapMap Consortium (2005) A haplotype map of the human genome. Nature 449 (7164): 851–861.

International HapMap Consortium, Frazer KA, Ballinger DG, et al. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 437 (7063): 1299–1320.

Kang J, Shi Y, Xiang B, et al. (2005) A nuclear function of β‐arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 (5): 833–847.

Kim EB, Fang X, Fushan AA, et al. (2011) Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 479 (7372): 223–227.

Li Z, Wan X, Li X and Li J (2010) Research output in immunology journals from Chinese authors: 10‐year survey of literature. Immunological Investigations 39 (3): 206–218.

Meng S‐D, Gao T, Gao GF and Tien P (2001) HBV‐specific peptide associated with heat‐shock protein gp96. The Lancet 357 (9255): 528–529.

Miller LH and Su X (2011) Artemisinin: discovery from the Chinese herbal garden. Cell 146 (6): 855–858.

Poo MM (2010) Neuroscience in China 2000–2009: introduction. Science China. Life Sciences 53 (3): 301–303.

Qiang M, Wu B and Liu Y (2011) A brief review on current progress in neuroscience in China. Science China. Life Sciences 54 (12): 1156–1159.

She J, Han Z, Kim TW, et al. (2011) Structural insight into brassinosteroid perception by BRI1. Nature 474 (7352): 472–476.

Shen JX, Feng AS, Xu ZM, et al. (2008) Ultrasonic frogs show hyperacute phonotaxis to female courtship calls. Nature 453 (7197): 914–916.

Wu J, Xiao J and Yu J (2012) Latest notable achievements in genomics. Science China. Life Sciences 55 (7): 645–648.

Tang S and Guo A (2001) Choice behavior of Drosophila facing contradictory visual cues. Science 294 (5546): 1543–1547.

Xia Q, Zhou Z, Lu C, et al. (2004) A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science 306 (5703): 1937–1940.

Xu J, Li H‐D, Chen L‐Q, et al. (2006) A protein kinase, interacting with two calcineurin B‐like proteins, regulates K+ transporter AKT1 in Arabidopsis. Cell 125 (7): 1347–1360.

Yue R, Kang J, Zhao C, et al. (2009) Beta‐arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb grouprepression. Cell 139 (3): 535–546.

Zhang Q (2007) Strategies for developing green super rice. Proceedings of the National Academy of Sciences of the United States of America 104 (42): 16402–16409.

Zhang K, Guo JZ, Peng Y, Xi W and Guo A (2007) Dopamine‐mushroom body circuit regulates saliency‐based decision‐making in Drosophila. Science 316 (5833): 1901–1904.

Zhang G, Cowled C, Shi Z, et al. (2013) Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. Science 339 (6118): 456–460.

Zuo J and Li J (2014) Molecular dissection of complex agronomic traits of rice: a team effort by Chinese scientists in recent years. National Science Review 1: 253–276.

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Wang, Yihuang, Wen, Zhaojun, and Chen, Zhu(Feb 2015) Life Sciences in China. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0025083]