RNA Silencing

RNA-mediated gene silencing targets host genes and RNA species and has been shown to be involved in development, growth and response to external stimuli in both animals and plants as well as protecting cells against insults, such as viruses and transposons. Utilization of this mechanism in applied research is referred to as RNA interference (RNAi). RNAi is being developed as a treatment for virus infections, cardiovascular diseases, cancer, endocrine disorders and numerous other conditions.


Noncoding RNAs in Biology and Disease
Maciej Szymański, Jan Barciszewski
Published online: March 2009
Noncoding RNAs: A Regulatory Role?
John Stanley Mattick
Published online: January 2006
Regulatory RNA
E Gerhart H Wagner, Shoshy Altuvia, Wolfgang Nellen
Published online: April 2001
Small Regulatory RNAs in Bacteria
Nicholas Delihas
Published online: March 2009
Small RNAs in Neurological Disorders
Li Lin, Angela V Vitale, Peng Jin
Published online: April 2010
Small RNAs in Plants
Franck Vazquez
Published online: March 2009
MicroRNAs (miRNAs) and Plant Development
Wang‐Xia Wang, Bobby Gaffney, Arthur G. Hunt, Guiliang Tang
Published online: July 2007
MicroRNAs and Human Disease
Christian Marin‐Muller, Qizhi Yao, Changyi Chen
Published online: October 2010
MicroRNAs in Animal Development
Jennifer H Mansfield
Published online: March 2010
MicroRNAs in Cancer
Reinhold Munker, George A Calin
Published online: March 2011
MicroRNAs in Cardiovascular Disease
Ronald L Neppl, Da‐Zhi Wang
Published online: June 2010
MicroRNAs in Development and Disease
Alison A Staton, Antonio J Giraldez
Published online: July 2008
RNA Interference (RNAi) and MicroRNAs
Gregory J Hannon
Published online: September 2006
Nonprotein‐coding Genes
David Tollervey
Published online: September 2005
Small Silencing RNAs and Gene Therapy
Dirk Grimm
Published online: June 2010
Plant Virus Movement and the Impact of RNA Silencing
Manfred Heinlein
Published online: December 2009
Plant Virus Silencing Suppressors and RNA Silencing in Plants
Feng Qu, T Jack Morris
Published online: December 2007
RNA Silencing and its Suppressors in the Plant‐virus Interplay
Adrián Valli, Juan José López‐Moya, Juan Antonio García
Published online: September 2009
Synthetic Nucleic Acid Delivery Systems in Gene Therapy
Andrew David Miller
Published online: March 2008