Mutations and the Genetic Code


Mutations may change the coding function of the genome. The outcome of a mutation depends on the type of change and its location within or near genes.

Keywords: genetics; mutation; genetic code

Further Reading

Altuvia S, Kornitzer D, Teff D and Oppenheim AB (1989) Alternative mRNA structures of the cIII gene of bacteriophage lambda determine the rate of its translation initiation. Journal of Molecular Biology 210: 265–280.

Bacino C, Prezant TR, Bu X, Fournier P and Fischel‐Ghodsian N (1995) Susceptibility mutations in the mitochondrial small ribosomal RNA gene in aminoglycoside induced deafness. Pharmacogenetics 5: 165–172.

Ciotta C, Dogliotti E and Bignami M (1995) Mutation analysis in two newly identified rat p53 pseudogenes. Mutagenesis 10: 123–128.

Ripley LS (1990) Frameshift mutation: determinants of specificity. Annual Review of Genetics 24: 189–213.

Shoffner JM (1996) Maternal inheritance and the evaluation of oxidative phosphorylation diseases. Lancet 348: 1283–1288.

Streisinger G, Okada Y, Emrich J et al. (1966) Frameshift mutations and the genetic code. Cold Spring Harbor Symposia on Quantitative Biology 31: 77–84.

Toft NJ and Arends MJ (1998) DNA mismatch repair and colorectal cancer. Journal of Pathology 185: 123–129.

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How to Cite close
De Boer, Johan G(Jul 2003) Mutations and the Genetic Code. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0000823]